Table 4: Association of SORL1 three-marker haplotypes (rs11218304-rs689021-rs11218343) with Amci
Haplotypes | aMCI (freq) | Controls (freq) | Fisher's Punadj value | OR (95% CI) |
A-C-C | 24.43 (0.194) | 35.49 (0.099) | 0.005062 | 2.206 (1.257-3.873) |
A-C-T | 24.51 (0.195) | 66.69 (0.186) | 0.819670 | 1.062 (0.633-1.780) |
A-T-C | 17.41 (0.138) | 39.35 (0.110) | 0.381657 | 1.308 (0.713-2.396) |
A-T-T | 44.65 (0.354) | 169.47 (0.473) | 0.021905 | 0.611 (0.400-0.933) |
G-C-T | 5.91 (0.047) | 35.65 (0.100) | 0.071315 | 0.447 (0.182-1.095) |
G-T-T | 5.93 (0.047) | 4.18 (0.012) | 0.016384 | 4.210 (1.183-14.978) |
Freq = frequency. Haplotypes were omitted from analysis if the estimated haplotype probabilities were less than 3%