Table 2: Association study of three SNPs in SORL1 under different models
Control | aMCI | |||||
SNP(A1/A2)†/Test Model | n | Freq. § | n | Freq. § | Punadj* | Padj* |
rs11218304(C;T) | ||||||
Trend: C/T | 47/311 | 13.1% | 15/111 | 11.9% | 0.7188 | 1.000 |
Allelic: C/T | 47/311 | 13.1% | 15/111 | 11.9% | 0.7237 | 1.000 |
Dominant: (CC+CT)/TT | 45/134 | 1.12% | 14/49 | 22.2% | NA | NA |
Recessive: CC/(CT+TT) | 2/177 | 1/62 | 1.59% | NA | NA | |
rs689021 (G;A) | ||||||
Trend: G/A | 145/213 | 40.5% | 58/68 | 46.0% | 0.2852 | 0.856 |
Allelic: G/A | 145/213 | 40.5% | 58/68 | 46.0% | 0.2794 | 0.838 |
Dominant: (GG+GA)/AA | 114/65 | 63.7% | 45/18 | 71.4% | 0.2656 | 0.797 |
Recessive: GG/(GA+AA) | 31/148 | 17.3% | 13/50 | 20.6% | 0.5572 | 1.000 |
rs11218343 (C;T) | ||||||
Trend: C/T | 82/276 | 22.9% | 45/81 | 35.7% | 0.004209 | 0.013 |
Allelic: C/T | 82/276 | 22.9% | 45/81 | 35.7% | 0.004941 | 0.015 |
Dominant: (CC+CT)/TT | 76/103 | 42.5% | 36/27 | 57.1% | 0.04438 | 0.133 |
Recessive: CC/(CT+TT) | 6/173 | 3.35% | 9/54 | 14.3% | 0.001966 | 0.006 |
†A1/A2, indicates minor allele/major allele
§The minor allele frequency for allelic and trend model, "DD+Dd" frequency for dominant model, and "DD" for recessive model, where "D" indicates minor allele, "d" indicates the major allele
Padj is adjusted by Bonferroni correction.
*Cochran-Armitage trend test p-value for the Trend model; for other models, asymptotic p-value was calculated by Chi-Squared test