Table 2: Association study of three SNPs in SORL1 under different models

Control aMCI
SNP(A1/A2)/Test Model n Freq. n Freq. Punadj* Padj*
rs11218304(C;T)
     Trend: C/T 47/311 13.1% 15/111 11.9% 0.7188 1.000
     Allelic: C/T 47/311 13.1% 15/111 11.9% 0.7237 1.000
     Dominant: (CC+CT)/TT 45/134 1.12% 14/49 22.2% NA NA
     Recessive: CC/(CT+TT) 2/177 1/62 1.59% NA NA
rs689021 (G;A)
     Trend: G/A 145/213 40.5% 58/68 46.0% 0.2852 0.856
     Allelic: G/A 145/213 40.5% 58/68 46.0% 0.2794 0.838
     Dominant: (GG+GA)/AA 114/65 63.7% 45/18 71.4% 0.2656 0.797
     Recessive: GG/(GA+AA) 31/148 17.3% 13/50 20.6% 0.5572 1.000
rs11218343 (C;T)
     Trend: C/T 82/276 22.9% 45/81 35.7% 0.004209 0.013
     Allelic: C/T 82/276 22.9% 45/81 35.7% 0.004941 0.015
     Dominant: (CC+CT)/TT 76/103 42.5% 36/27 57.1% 0.04438 0.133
     Recessive: CC/(CT+TT) 6/173 3.35% 9/54 14.3% 0.001966 0.006

A1/A2, indicates minor allele/major allele
The minor allele frequency for allelic and trend model, "DD+Dd" frequency for dominant model, and "DD" for recessive model, where "D" indicates minor allele, "d" indicates the major allele
Padj is adjusted by Bonferroni correction.
*Cochran-Armitage trend test p-value for the Trend model; for other models, asymptotic p-value was calculated by Chi-Squared test