Table 3: Cluster of hot spot residues on FANCD2 interface of interaction.
Chain | Residue | KFC2-A* | KFC2-B** | Partner |
a | ARG 591 | 0.25 | 0.30 | RAD51a |
a | HIS 594# | 0.96 | 0.24 | RAD51a |
a | GLN 597 | 0.56 | 0.02 | RAD51a |
a | ARG 648 | 0.82 | 0.10 | RAD51a |
a | ILE 849# | 0.32 | 0.05 | RAD51a |
a | ILE 855# | 0.64 | 0.16 | RAD51a |
a | ARG 879# | 1.12 | 0.34 | RAD51a |
a | ARG 886# | 0.74 | 0.32 | RAD51a |
a | LEU 889 | 1.74 | 0.31 | RAD51a |
*Hot spot model based on shape specificity features; **Hot spot model based on biochemical features such as intermolecular hydrogen bonds; #Polymorphic residues that may greatly affect the free energy binding of FANCD2 to RAD51a.