Table 2: Cluster of hot spot residues on PCNA interface of interaction.

Chain Residue KFC2-A* KFC2-B** Partner
d TYR 151# 0.35 0.11 RAD51a
d HIS 152 1.70 0.15 RAD51a
d LYS 154# 1.73 0.14 RAD51a
d ARG 156 1.49 0.34 RAD51a
d LEU 157# 1.42 0.09 RAD51a
d ILE 158 1.32 0.29 RAD51a
d PHE 159 1.12 0.12 RAD51a

*Hot spot model based on shape specificity features; **Hot spot model based on biochemical features such as intermolecular hydrogen bonds; #Polymorphic residues that may greatly affect the free energy binding of PCNA to RAD51a.