Table 2: Cluster of hot spot residues on PCNA interface of interaction.
Chain | Residue | KFC2-A* | KFC2-B** | Partner |
d | TYR 151# | 0.35 | 0.11 | RAD51a |
d | HIS 152 | 1.70 | 0.15 | RAD51a |
d | LYS 154# | 1.73 | 0.14 | RAD51a |
d | ARG 156 | 1.49 | 0.34 | RAD51a |
d | LEU 157# | 1.42 | 0.09 | RAD51a |
d | ILE 158 | 1.32 | 0.29 | RAD51a |
d | PHE 159 | 1.12 | 0.12 | RAD51a |
*Hot spot model based on shape specificity features; **Hot spot model based on biochemical features such as intermolecular hydrogen bonds; #Polymorphic residues that may greatly affect the free energy binding of PCNA to RAD51a.