Table 1: Cluster of hot spot residues on RAD51a interface of interaction.
Chain | Residue | KFC2-A* | KFC2-B** | Partner |
A | ARG 251 | 0.97 | 0.16 | PCN |
F | PHE 137 | 0.38 | 0.18 | PCN |
F | GLN 258 | 0.39 | 0.04 | PCN |
F | HIS 303 | 1.56 | 0.10 | PCN |
G | ILE 249 | 1.10 | 0.17 | PCN |
G | ARG 251 | 0.73 | 0.09 | PCN |
G | LEU 254 | 0.28 | 0.04 | PCN |
A | ILE 249 | 1.45 | 0.20 | FANCD2 |
A | ARG 251 | 1.68 | 0.28 | FANCD2 |
E | PHE 137 | 1.27 | 0.34 | FANCD2 |
E | ARG 251 | 0.93 | 0.10 | FANCD2 |
E | LEU 254 | 0.40 | 0.07 | FANCD2 |
E | GLN 258 | 0.69 | 0.06 | FANCD2 |
E | HIS 303 | 1.25 | 0.01 | FANCD2 |
E | ILE 304 | 0.39 | 0.11 | FANCD2 |
E | TYR 314 | 1.25 | 0.30 | FANCD2 |
F | ILE 249 | 1.14 | 0.15 | FANCD2 |
F | ARG 251 | 1.31 | 0.20 | FANCD2 |
D | LEU 254 | 0.97 | 0.13 | ABL1-SH3 |
E | ARG 251 | 1.79 | 0.33 | ABL1-SH3 |
E | LEU 254 | 1.44 | 0.31 | ABL1-SH3 |
E | ARG 257 | 0.53 | 0.25 | ABL1-SH3 |
F | ILE 249 | 1.34 | 0.26 | ABL1-SH3 |
A | PHE 137 | 1.44 | 0.39 | ABL1-TK |
A | ARG 251 | 1.20 | 0.23 | ABL1-TK |
A | LEU 254 | 1.04 | 0.24 | ABL1-TK |
A | ARG 257 | 0.17 | 0.11 | ABL1-TK |
A | GLN 258 | 0.66 | 0.15 | ABL1-TK |
A | HIS 303 | 1.92 | 0.33 | ABL1-TK |
A | ILE 304 | 0.73 | 0.20 | ABL1-TK |
A | LEU 305 | 1.39 | 0.27 | ABL1-TK |
A | ILE 328 | 0.91 | 0.05 | ABL1-TK |
B | ARG 245 | 0.81 | 0.05 | ABL1-TK |
*Hot spot model based on shape specificity features; **Hot spot model based on biochemical features such as intermolecular hydrogen bonds.