Table 2: Associations
between Genotyped SNPs in Circadian Genes and EOC Incidence Overall, in
Histological Subtypes, and Invasiveness.
|
|
|
|
|
|
All
invasive |
|
Serous |
|
Clear
cell |
|
|
Gene |
SNP |
Chr |
Min/Maj |
MAF |
OR (95% CI) |
p |
OR (95% CI) |
p |
OR (95% CI) |
p |
|
BMAL1 |
rs1026071 |
11 |
G/A |
0.30 |
0.98 (0.95-1.01) |
2.26 × 10-01 |
1.00 (0.96-1.04) |
9.38 × 10-01 |
0.88 (0.8-0.98) |
1.55
× 10-02 |
|
BMAL1 |
rs10732458 |
11 |
A/G |
0.02 |
1.11 (0.99-1.23) |
6.91 × 10-02 |
1.10 (0.96-1.25) |
1.64 × 10-01 |
1.19 (0.88-1.6) |
2.52 × 10-01 |
|
BMAL1 |
rs10832027 |
11 |
G/A |
0.33 |
0.98 (0.95-1.02) |
3.48 × 10-01 |
1.00 (0.96-1.04) |
9.79 × 10-01 |
0.92 (0.84-1.01) |
9.15 × 10-02 |
|
BMAL1 |
rs1562438 |
11 |
A/G |
0.29 |
0.98 (0.95-1.02) |
3.07 × 10-01 |
1.00 (0.96-1.05) |
8.46 × 10-01 |
0.88 (0.80-0.97) |
1.35
× 10-02 |
|
BMAL1 |
rs16912751 |
11 |
G/A |
0.05 |
0.98 (0.92-1.05) |
6.23 × 10-01 |
0.96 (0.88-1.04) |
3.42 × 10-01 |
1.13 (0.93-1.37) |
2.18 × 10-01 |
|
BMAL1 |
rs2896635 |
11 |
T/A |
0.33 |
0.98 (0.95-1.02) |
3.14 × 10-01 |
1.00 (0.96-1.04) |
9.57 × 10-01 |
0.93 (0.84-1.02) |
1.17 × 10-01 |
|
BMAL1 |
rs3789327 |
11 |
G/A |
0.48 |
1.01 (0.98-1.04) |
5.34 × 10-01 |
1.01 (0.97-1.04) |
7.88 × 10-01 |
1.04 (0.95-1.14) |
4.17 × 10-01 |
|
BMAL1 |
rs3816360 |
11 |
A/G |
0.34 |
1.00 (0.96-1.03) |
7.75 × 10-01 |
1.02 (0.98-1.06) |
4.36 × 10-01 |
0.91 (0.82-1.00) |
4.31
× 10-02 |
|
BMAL1 |
rs4757151 |
11 |
A/G |
0.47 |
1.00 (0.97-1.04) |
7.76 × 10-01 |
1.01 (0.98-1.05) |
5.46 × 10-01 |
0.97 (0.89-1.06) |
5.20 × 10-01 |
|
BMAL1 |
rs6486122 |
11 |
G/A |
0.32 |
0.98 (0.95-1.02) |
2.83 × 10-01 |
1.00 (0.96-1.04) |
9.53 × 10-01 |
0.92 (0.83-1.01) |
8.10 × 10-02 |
|
BMAL1 |
rs7117836 |
11 |
A/G |
0.02 |
1.10 (0.99-1.22) |
8.49 × 10-02 |
1.09 (0.96-1.24) |
1.65 × 10-01 |
1.19 (0.89-1.59) |
2.46 × 10-01 |
|
BMAL1 |
rs7947951 |
11 |
A/G |
0.32 |
0.99 (0.95-1.02) |
3.60 × 10-01 |
1.00 (0.96-1.04) |
9.13 × 10-01 |
0.92 (0.84-1.01) |
9.30 × 10-02 |
|
CRY2 |
rs11038695 |
11 |
A/G |
0.08 |
1.05 (0.99-1.11) |
1.11 × 10-01 |
1.03 (0.97-1.11) |
3.40 × 10-01 |
0.99 (0.84-1.17) |
9.25 × 10-01 |
|
CSNK1E |
rs135750 |
22 |
G/C |
0.15 |
1.04 (1.00-1.09) |
6.14 × 10-02 |
1.03 (0.98-1.08) |
3.12 × 10-01 |
1.00 (0.89-1.13) |
9.73 × 10-01 |
|
KLF10 |
rs12547834 |
8 |
G/A |
0.07 |
0.96 (0.90-1.02) |
1.43 × 10-01 |
0.94 (0.88-1.02) |
1.20 × 10-01 |
1.02 (0.85-1.21) |
8.49 × 10-01 |
|
KLF10 |
rs3191333 |
8 |
A/G |
0.37 |
1.04 (1.01-1.07) |
2.42
× 10-02 |
1.05 (1.02-1.10) |
6.72
× 10-03 |
1.04 (0.95-1.14) |
3.95 × 10-01 |
|
KLF10 |
rs980112 |
8 |
A/G |
0.10 |
0.97 (0.92-1.02) |
1.98 × 10-01 |
0.96 (0.90-1.03) |
2.42 × 10-01 |
1.06 (0.92-1.23) |
4.08 × 10-01 |
|
KLF10 |
rs2388232 |
8 |
G/A |
0.27 |
1.01 (0.97-1.04) |
7.92 × 10-01 |
1.00 (0.96-1.04) |
9.22 × 10-01 |
1.11 (1.01-1.23) |
2.91
× 10-02 |
|
KLF10 |
rs2511703 |
8 |
G/A |
0.43 |
1.04 (1.01-1.07) |
1.83
× 10-02 |
1.05 (1.02-1.09) |
6.54
× 10-03 |
1.00 (0.91-1.09) |
9.55 × 10-01 |
|
KLF10 |
rs2513927 |
8 |
A/G |
0.49 |
1.04 (1.01-1.07) |
1.86
× 10-02 |
1.05 (1.01-1.09) |
1.18
× 10-02 |
1.00 (0.91-1.10) |
9.79 × 10-01 |
|
KLF10 |
rs2513928 |
8 |
G/A |
0.46 |
0.95 (0.92-0.98) |
1.75
× 10-03 |
0.94 (0.91-0.98) |
2.42
× 10-03 |
0.94 (0.85-1.02) |
1.50 × 10-01 |
|
KLF10 |
rs2511660 |
8 |
A/G |
0.22 |
0.97 (0.94-1.01) |
1.57 × 10-01 |
0.96 (0.92-1.00) |
6.95 × 10-02 |
0.99 (0.89-1.10) |
8.56 × 10-01 |
|
KLF10 |
rs2511718 |
8 |
A/G |
0.12 |
0.98 (0.94-1.03) |
4.57 × 10-01 |
0.98 (0.92-1.04) |
4.47 × 10-01 |
1.06 (0.93-1.22) |
3.68 × 10-01 |
|
NPAS2 |
rs1053091 |
2 |
A/G |
0.02 |
1.05 (0.93-1.19) |
4.14 × 10-01 |
1.10 (0.96-1.27) |
1.83 × 10-01 |
1.12 (0.79-1.59) |
5.17 × 10-01 |
|
NPAS2 |
rs13012930 |
2 |
A/G |
0.17 |
0.96 (0.92-1.00) |
4.80
× 10-02 |
0.95 (0.91-1.00) |
4.11
× 10-02 |
0.98 (0.87-1.10) |
6.86 × 10-01 |
|
NPAS2 |
rs3768988 |
2 |
G/A |
0.06 |
1.01 (0.95-1.07) |
8.18 × 10-01 |
1.02 (0.94-1.10) |
6.44 × 10-01 |
1.01 (0.84-1.22) |
9.09 × 10-01 |
|
NPAS2 |
rs7573323 |
2 |
A/G |
0.03 |
0.97 (0.88-1.07) |
5.47 × 10-01 |
0.99 (0.88-1.11) |
8.61 × 10-01 |
0.87 (0.65-1.18) |
3.73 × 10-01 |
|
PER3 |
rs228644 |
1 |
A/G |
0.40 |
1.00 (0.97-1.03) |
9.23 × 10-01 |
1.00 (0.96-1.03) |
8.38 × 10-01 |
0.97 (0.89-1.07) |
5.45 × 10-01 |
|
PER3 |
rs228682 |
1 |
G/A |
0.40 |
1.00 (0.97-1.03) |
7.83 × 10-01 |
0.99 (0.96-1.03) |
7.32 × 10-01 |
0.97 (0.88-1.06) |
4.84 × 10-01 |
|
PER3 |
rs228698 |
1 |
A/G |
0.04 |
1.00 (0.93-1.08) |
9.73 × 10-01 |
0.99 (0.90-1.08) |
7.67 × 10-01 |
0.90 (0.71-1.14) |
3.79 × 10-01 |
|
PER3 |
rs697693 |
1 |
A/G |
0.19 |
0.99 (0.95-1.03) |
5.55 × 10-01 |
0.98 (0.94-1.03) |
5.02 × 10-01 |
1.07 (0.96-1.19) |
2.46 × 10-01 |
|
REV1 |
rs3792152 |
2 |
A/G |
0.44 |
0.97 (0.94-1.00) |
6.47 × 10-02 |
0.97 (0.94-1.01) |
1.34 × 10-01 |
0.99 (0.90-1.08) |
7.96 × 10-01 |
|
SENP3 |
rs6608 |
17 |
A/G |
0.17 |
1.05 (1.00-1.09) |
3.35
× 10-02 |
1.04 (0.99-1.09) |
1.42 × 10-01 |
1.01 (0.90-1.14) |
8.81 × 10-01 |
|
TIMELESS |
rs7302060 |
12 |
G/A |
0.41 |
0.99 (0.96-1.02) |
3.53 × 10-01 |
0.98 (0.94-1.01) |
2.09 × 10-01 |
0.97 (0.88-1.06) |
4.77 × 10-01 |
|
|
|
Endometriod |
|
Mucinous |
|
LMP vs. controls |
|
Invasive vs. LMP |
|
|
Gene |
SNP |
OR (95% CI) |
p |
OR
(95% CI) |
p |
OR
(95% CI) |
p |
OR
(95% CI) |
p |
|
BMAL1 |
rs1026071 |
0.98 (0.91-1.05) |
5.17 × 10-01 |
0.94 (0.85-1.05) |
2.63 × 10-01 |
0.99 (0.92-1.07) |
8.95 × 10-01 |
1.00 (0.92-1.08) |
9.17 × 10-01 |
|
BMAL1 |
rs10732458 |
1.32 (1.07-1.63) |
9.64
× 10-03 |
1.02 (0.72-1.44) |
9.12 × 10-01 |
0.77 (0.58-1.02) |
6.51 × 10-02 |
1.44 (1.09-1.92) |
1.17
× 10-02 |
|
BMAL1 |
rs10832027 |
0.99 (0.93-1.06) |
8.48 × 10-01 |
0.95 (0.86-1.05) |
2.75 × 10-01 |
1.00 (0.93-1.07) |
9.17 × 10-01 |
1.00 (0.92-1.07) |
9.04 × 10-01 |
|
BMAL1 |
rs1562438 |
0.97 (0.90-1.04) |
4.12 × 10-01 |
0.94 (0.85-1.05) |
2.74 × 10-01 |
1.00 (0.93-1.08) |
9.79 × 10-01 |
0.99 (0.92-1.07) |
8.80 × 10-01 |
|
BMAL1 |
rs16912751 |
0.90 (0.78-1.05) |
1.97 × 10-01 |
1.11 (0.91-1.36) |
2.94 × 10-01 |
0.88 (0.75-1.04) |
1.40 × 10-01 |
1.12 (0.95-1.33) |
1.73 × 10-01 |
|
BMAL1 |
rs2896635 |
0.99 (0.92-1.06) |
7.20 × 10-01 |
0.95 (0.86-1.05) |
3.04 × 10-01 |
1.00 (0.93-1.07) |
9.49 × 10-01 |
0.99 (0.92-1.07) |
8.21 × 10-01 |
|
BMAL1 |
rs3789327 |
1.00 (0.94-1.07) |
9.84 × 10-01 |
0.95 (0.86-1.04) |
2.53 × 10-01 |
1.01 (0.94-1.08) |
8.63 × 10-01 |
1.01 (0.94-1.08) |
8.01 × 10-01 |
|
BMAL1 |
rs3816360 |
0.99 (0.92-1.06) |
7.74 × 10-01 |
0.94 (0.85-1.04) |
2.52 × 10-01 |
1.02 (0.94-1.09) |
6.67 × 10-01 |
0.99 (0.92-1.06) |
7.53 × 10-01 |
|
BMAL1 |
rs4757151 |
0.99 (0.92-1.05) |
6.91 × 10-01 |
1.06 (0.97-1.17) |
1.97 × 10-01 |
0.98 (0.91-1.05) |
5.61 × 10-01 |
1.03 (0.96-1.11) |
3.73 × 10-01 |
|
BMAL1 |
rs6486122 |
0.99 (0.92-1.06) |
6.90 × 10-01 |
0.95 (0.86-1.05) |
3.12 × 10-01 |
0.99 (0.92-1.07) |
8.62 × 10-01 |
0.99 (0.92-1.07) |
8.83 × 10-01 |
|
BMAL1 |
rs7117836 |
1.24 (1.01-1.54) |
4.40
× 10-02 |
1.06 (0.76-1.48) |
7.36 × 10-01 |
0.76 (0.57-1.00) |
4.82
× 10-02 |
1.45 (1.09-1.92) |
9.81
× 10-03 |
|
BMAL1 |
rs7947951 |
0.99 (0.93-1.06) |
8.17 × 10-01 |
0.95 (0.86-1.05) |
2.94 × 10-01 |
1.00 (0.93-1.07) |
9.34 × 10-01 |
0.99 (0.92-1.07) |
8.78 × 10-01 |
|
CRY2 |
rs11038695 |
1.09 (0.97-1.22) |
1.48 × 10-01 |
0.97 (0.82-1.15) |
7.19 × 10-01 |
1.07 (0.94-1.21) |
2.88 × 10-01 |
0.98 (0.86-1.11) |
7.02 × 10-01 |
|
CSNK1E |
rs135750 |
1.13 (1.03-1.23) |
7.09
× 10-03 |
1.06 (0.93-1.20) |
3.90 × 10-01 |
1.02 (0.93-1.12) |
6.98 × 10-01 |
1.03 (0.93-1.13) |
6.10 × 10-01 |
|
KLF10 |
rs12547834 |
0.99 (0.87-1.13) |
8.75 × 10-01 |
0.86 (0.71-1.04) |
1.22 × 10-01 |
0.97 (0.84-1.11) |
6.56 × 10-01 |
0.99 (0.86-1.14) |
8.87 × 10-01 |
|
KLF10 |
rs3191333 |
1.03 (0.96-1.10) |
3.84 × 10-01 |
0.95 (0.86-1.05) |
3.01 × 10-01 |
0.99 (0.92-1.06) |
7.70 × 10-01 |
1.05 (0.97-1.13) |
2.21 × 10-01 |
|
KLF10 |
rs980112 |
0.95 (0.85-1.06) |
3.49 × 10-01 |
0.90 (0.76-1.05) |
1.85 × 10-01 |
0.99 (0.88-1.12) |
8.95 × 10-01 |
0.98 (0.87-1.11) |
7.73 × 10-01 |
|
KLF10 |
rs2388232 |
0.99 (0.92-1.06) |
7.81 × 10-01 |
0.98 (0.88-1.08) |
6.40 × 10-01 |
1.03 (0.96-1.12) |
3.86 × 10-01 |
0.97 (0.90-1.05) |
4.71 × 10-01 |
|
KLF10 |
rs2511703 |
1.05 (0.98-1.12) |
1.34 × 10-01 |
0.95 (0.87-1.05) |
3.17 × 10-01 |
0.98 (0.91-1.05) |
5.75 × 10-01 |
1.06 (0.98-1.13) |
1.32 × 10-01 |
|
KLF10 |
rs2513927 |
1.05 (0.99-1.13) |
1.11 × 10-01 |
0.94 (0.85-1.03) |
1.71 × 10-01 |
0.98 (0.92-1.05) |
5.94 × 10-01 |
1.06 (0.99-1.13) |
1.24 × 10-01 |
|
KLF10 |
rs2513928 |
0.95 (0.89-1.01) |
1.20 × 10-01 |
1.02 (0.93-1.12) |
6.88 × 10-01 |
0.96 (0.90-1.03) |
2.56 × 10-01 |
0.99 (0.92-1.06) |
6.95 × 10-01 |
|
KLF10 |
rs2511660 |
1.02 (0.94-1.10) |
6.80 × 10-01 |
0.96 (0.85-1.07) |
4.38 × 10-01 |
1.06 (0.98-1.15) |
1.43 × 10-01 |
0.92 (0.85-1.00) |
4.47
× 10-02 |
|
KLF10 |
rs2511718 |
0.96 (0.87-1.06) |
4.28 × 10-01 |
0.95 (0.82-1.09) |
4.52 × 10-01 |
1.01 (0.91-1.13) |
8.02 × 10-01 |
0.97 (0.87-1.09) |
6.41 × 10-01 |
|
NPAS2 |
rs1053091 |
0.84 (0.64-1.12) |
2.45 × 10-01 |
1.02 (0.71-1.47) |
9.00 × 10-01 |
1.10 (0.85-1.44) |
4.69 × 10-01 |
0.93 (0.71-1.22) |
5.88 × 10-01 |
|
NPAS2 |
rs13012930 |
1.02 (0.93-1.11) |
7.23 × 10-01 |
0.91 (0.80-1.03) |
1.31 × 10-01 |
1.04 (0.95-1.14) |
3.73 × 10-01 |
0.92 (0.84-1.01) |
9.47 × 10-02 |
|
NPAS2 |
rs3768988 |
0.93 (0.81-1.07) |
3.02 × 10-01 |
1.01 (0.84-1.22) |
8.90 × 10-01 |
1.09 (0.95-1.26) |
2.06 × 10-01 |
0.93 (0.80-1.07) |
2.83 × 10-01 |
|
NPAS2 |
rs7573323 |
0.92 (0.74-1.13) |
4.13 × 10-01 |
0.83 (0.60-1.16) |
2.78 × 10-01 |
0.83 (0.66-1.05) |
1.12 × 10-01 |
1.18 (0.93-1.49) |
1.76 × 10-01 |
|
PER3 |
rs228644 |
0.97 (0.91-1.04) |
3.76 × 10-01 |
1.07 (0.97-1.17) |
1.82 × 10-01 |
0.99 (0.92-1.06) |
6.91 × 10-01 |
1.02 (0.95-1.09) |
6.69 × 10-01 |
|
PER3 |
rs228682 |
0.97 (0.91-1.04) |
3.51 × 10-01 |
1.07 (0.97-1.17) |
1.90 × 10-01 |
0.98 (0.92-1.06) |
6.37 × 10-01 |
1.02 (0.95-1.09) |
6.65 × 10-01 |
|
PER3 |
rs228698 |
1.04 (0.89-1.23) |
6.04 × 10-01 |
1.08 (0.86-1.36) |
4.89 × 10-01 |
0.96 (0.81-1.15) |
6.66 × 10-01 |
1.01 (0.85-1.21) |
8.76 × 10-01 |
|
PER3 |
rs697693 |
0.99 (0.91-1.08) |
8.61 × 10-01 |
0.92 (0.81-1.04) |
1.67 × 10-01 |
1.04 (0.95-1.13) |
3.81 × 10-01 |
0.96 (0.88-1.05) |
3.45 × 10-01 |
|
REV1 |
rs3792152 |
0.92 (0.86-0.98) |
9.61
× 10-03 |
0.99 (0.90-1.09) |
8.32 × 10-01 |
0.98 (0.91-1.05) |
4.87 × 10-01 |
1.01 (0.94-1.09) |
7.65 × 10-01 |
|
SENP3 |
rs6608 |
1.13 (1.04-1.23) |
4.43
× 10-03 |
1.00 (0.88-1.14) |
9.90 × 10-01 |
1.01 (0.92-1.10) |
9.00 × 10-01 |
1.04 (0.94-1.14) |
4.79 × 10-01 |
|
TIMELESS |
rs7302060 |
1.01 (0.95-1.08) |
7.22 × 10-01 |
0.97 (0.88-1.07) |
5.10 × 10-01 |
0.93 (0.87-1.00) |
4.86
× 10-02 |
1.06 (0.99-1.14) |
1.09 × 10-01 |
SNP: Single Nucleotide Polymorphism, Chr: Chromosome,
Min/Maj: Minor and Major Allele, MAF: Minor Allele Frequency, LMP: Low Malignant
Potential, OR: Odds Ratio
Note: odds ratio is calculated based on per-minor allele,
bolded SNPs indicate an association of p < 0.05 with overall EOC or
histologic subtype.