Table 2: Causes of raised serum ferritin with iron overload [19].
Personal history of iron
overload |
Heavy oral, intravenous iron
supplements or many transfusion history. |
Chronic Anemia with ineffective
erythropoiesis (thalassemia intermedia, sideroblastic anemia, chronic
hemolytic anemia |
Full blood count, blood film,
haemoglobinopathy studies. |
Hereditary haemochromatosis |
Check for fatigue, lethargy,
arthralgia, diabetes, loss of libido, impotence, amenorrhoea, right upper
quadrant abdominal pain, hepatomegaly, cirrhosis, chondrocalcinosis, skin
hyperpigmentation, heart failure. |
Family history of iron overload |
Check for positive family history. |
Porphyria cutanea tarda |
Check for cutaneous
photosensitivity. Check for liver dysfunction. |