Table 4: Recommendations for Colorectal Cancer Screening in High-Risk Individuals.
Risk Factor | Recommendation |
One first-degree relative with advanced adenoma or CRC at < 60 years of age or two first-degree relative with advanced adenoma or CRC at any age |
Colonoscopy every 5 years starting at age 40 years or 10 years younger than youngest affected relative's age at diagnosis, whichever is earlier |
Familial Adenomatous Polyposis (FAP) or family history of FAP | Colonoscopy or flexible sigmoidoscopy annually as appropriate starting at puberty until patient and physician determine appropriate time for colectomy |
Hereditary Non-Polyposis Colorectal Cancer(HNPCC or Lynch Syndrome) or family history of HNPCC |
Colonoscopy every 2 years starting at age 20-25 years until age 40; then annually after age 40 |
Crohn's Disease & Ulcerative Colitis | Generally recommend screening colonoscopy 8-10 years after initial diagnosis |
Advanced adenoma: adenoma 10 mm or greater, has villous elements, or high grade dysplasia
CRC: colorectal cancer