Table 1: Characteristics of Cannabinoid hyperemesis syndrome, Cyclic vomiting syndrome, Cannabis withdrawal, and Hyperemesis gravidarum.

Cannabinoid Hyperemesis Syndrome [15] Cyclic Vomiting Syndrome [40] Cannabis Withdrawal [16] Hyperemesis Gravidarum [18]
Cyclical severe nausea and vomiting Cyclical severe nausea and vomiting Cannabis discontinuation after heavy and long-term use Continued emesis during pregnancy with no other associated cause
Minimum weekly cannabis use Accompanying symptoms such as headache, photosensitivity, and/or vertigo Symptoms often start 24-72 hours after cessation Typically at least 5% weight loss
Symptom resolution following cannabis cessation Personal and/or family history of migraines Condition not ascribed to a separate medical problem Laboratory abnormalities may be present including electrolyte, thyroid, and liver changes

Brief symptom resolution during hot bathing

Physical and psychological stressors can trigger episodes

A minimum of three of the following within one week of cessation:



-Sleep problems

-Loss of appetite or weight loss


-Decreased mood

-A physical symptom resulting in distress such as headache, abdominal pain, tremor, diaphoresis, or fever

History of hyperemesis gravidarum is a risk factor for future pregnancies

Onset before the age of 50 years Mean age of onset 5 years in children and 37 years in adults Thought to be on the spectrum of nausea and vomiting of pregnancy