Table 2: Clinical trials of rectal cancer [78].

Study

Key inclusion criteria

Treatment

Outcomes

Ngan, et al. [71]

T3,T4

RT short course and immediate surgery

RT long course and delayed surgery

DFS: 67% vs. 66%

Recurrence: 9% vs. 14.2%

Van Djk, et al. [79]

Stage IV

RT short course + CAPOX + Bebazizumab

pCR: 26%

Tunio, et al. [80]

T4

RQnt QT with capecitabineT + neoadyuv

pCR: 85.4%

Bujko, et al. [70]

Stage IV

NUeoadyuvant RT short course + FOLFOX vs. QRT with 5-F

pCR: 21% vs. 9%

Garcia-Aguilera

T3,T4

RT with 5 FU

RT with 5 FU followed by FOLFOX x 4 weeks

pCR: 18% vs. 25%

 

DFS: Disease Free Survival, pCR: Pathologic Complete Response