NF-kB levels (ng/μg of protein) in nuclear extracts of LPS stimulated PBMCs in various co-infected subgroups of HIV-1 positive donors.

Table 4: NF-kB levels (ng/μg of protein) in nuclear extracts of LPS stimulated PBMCs in various co-infected subgroups of HIV-1 positive donors.

NF-kB levels

(ng/µg of protein)

Subgroups of various co-infections in HIV-1 +ve donors

HPgV +ve

(n = 60)

TTV +ve

(n = 48)

HPgV -ve/TTV -ve

(n = 54)

Rep

(n = 38)

Vol

(n = 22)

Rep

(n = 16)

Vol

(n = 32)

Rep

(n = 19)

Vol

(n = 35)

HPgV viremia on follow up

Total

Rep

Neg

(n = 24)

Pos

(n = 14)

Mean

12.1

8.1

20.4

6.5^a

6.9

2.6

0.3

0.3^b

10.3

4.2

2.4

1.2

9.7

3.1

2.1

0.8

Mean

6.9

6.4

13.9

4.9^a

2.7

1.8

0.7

0.4^b

5.3

2.3

4.9

2.1

5.1

2.1

2.6

1.9

Statistical comparisons: a: Significantly higher values, vs. Pos (p < 0.001) at enrollment (En) as well as on follow up (Fu); b: Significantly lower value in Vol category of donors in HPgV +ve subgroup vs. similar category of donors in other two subgroups (p < 0.001) at enrollment (En) as well as on follow up (Fu)

Note: The mean ± SD level of NF-kB (ng/µg of protein) in non-donor controls (n = 50) was 0.48 ± 0.08.