Table 2: CD4+ T cell count and HIV-1 viral load at enrollment and rates of their changes during follow up in various co-infected subgroups of HIV-1 positive donors.

 

 

 

 

 

 

 

 

Assessment parameters Level

Subgroups of various co-infections in HIV-1 +ve donors

HPgV +ve

(n = 60)

TTV +ve

(n = 48)

HPgV -ve/ TTV -ve

(n = 54)

Rep

(n = 38)

Vol

(n = 22)

Rep

(n = 16)

Vol

(n = 32)

Rep

(n = 19)

Vol

(n = 35)

HPgV viremia on follow up

Total

(n = 38)

Neg

(n = 24)

Pos

(n = 14)

CD4+ T cell

Count/Cumm

Mean

SD

800

101

806

112

795

96

759

134

750

106

802

100

777

88

756

106

Rate of fall*

Mean

SD

7.5

2.6

10.4

1.4a

5.8

1.1

2.2

0.8b,c

6.9

2.6

4.5

1.1

7.3

1.6

4.8

1.1

HIV-1 viral load

Level

(log10)

Mean

SD

4.1

0.11

4.1

0.15

4.1

0.1

3.4

0.1

3.8

0.15

3.7

0.19

3.8

0.15

3.6

0.2

Rate of increase (log10)**

Mean

SD

0.33

0.14

0.49

0.09a

0.25

0.08

0.12

0.04b,c

0.25

0.1

0.2

0.08

0.26

0.12

0.24

0.1

*Indicates changes per month over I year of post-enrollment follow up; **Indicates changes per year between 1st and 2nd year of post-enrollment follow up (vide materials and methods).

Statistical comparisons: a: Significantly higher value vs. Pos (p < 0.001); b: Significantly lower value compared to replacement (Rep) category of donors in HPgV +ve subgroup (p < 0.001); c: Significantly lower value in voluntary (Vol) donors in HPgV +ve subgroup compared to similar category of donors in other two subgroups (p < 0.001).

Note: The mean ± SD value for CD4+ T cell count/cumm in non-donor controls (n = 50) was 802 ± 178.