Table 2: CD4+ T cell count and HIV-1 viral load at enrollment and rates of their changes during follow up in various co-infected subgroups of HIV-1 positive donors.
Assessment parameters Level |
Subgroups of various co-infections in HIV-1 +ve donors |
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HPgV +ve (n = 60) |
TTV +ve (n = 48) |
HPgV -ve/ TTV -ve (n = 54) |
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Rep (n = 38) |
Vol (n = 22) |
Rep (n = 16) |
Vol (n = 32) |
Rep (n = 19) |
Vol (n = 35) |
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HPgV viremia on follow up |
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Total (n = 38) |
Neg (n = 24) |
Pos (n = 14) |
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CD4+ T cell |
Count/Cumm |
Mean SD |
800 101 |
806 112 |
795 96 |
759 134 |
750 106 |
802 100 |
777 88 |
756 106 |
Rate of fall* |
Mean SD |
7.5 2.6 |
10.4 1.4a |
5.8 1.1 |
2.2 0.8b,c |
6.9 2.6 |
4.5 1.1 |
7.3 1.6 |
4.8 1.1 |
|
HIV-1 viral load |
Level (log10) |
Mean SD |
4.1 0.11 |
4.1 0.15 |
4.1 0.1 |
3.4 0.1 |
3.8 0.15 |
3.7 0.19 |
3.8 0.15 |
3.6 0.2 |
Rate of increase (log10)** |
Mean SD |
0.33 0.14 |
0.49 0.09a |
0.25 0.08 |
0.12 0.04b,c |
0.25 0.1 |
0.2 0.08 |
0.26 0.12 |
0.24 0.1 |
*Indicates changes per month over I year of post-enrollment follow up; **Indicates changes per year between 1st and 2nd year of post-enrollment follow up (vide materials and methods).
Statistical comparisons: a: Significantly higher value vs. Pos (p < 0.001); b: Significantly lower value compared to replacement (Rep) category of donors in HPgV +ve subgroup (p < 0.001); c: Significantly lower value in voluntary (Vol) donors in HPgV +ve subgroup compared to similar category of donors in other two subgroups (p < 0.001).
Note: The mean ± SD value for CD4+ T cell count/cumm in non-donor controls (n = 50) was 802 ± 178.