Mean ± SEM Levels of IFN-γ (μg mL<sup>-1</sup>) in supernatant of PBMC culture from HIV-1 positive blood donors stimulated with mitogen (PHA), M.tb specific antigen (PPD) and BCG with or without supplementation of recombinant IL-12 (rIL-12).

Table 3: Mean ± SEM Levels of IFN-γ (μg mL^-1) in supernatant of PBMC culture from HIV-1 positive blood donors stimulated with mitogen (PHA), M.tb specific antigen (PPD) and BCG with or without supplementation of recombinant IL-12 (rIL-12).

Stimulus	Replacement (n = 70)		Voluntary (n = 74)		Control (n = 100)
	First TST	Second TST	First TST	Second TST
PHA	9.6 ± 6.4	10.4 ± 4.6	12.4 ± 6.6	11.6 ± 6.2	11.2 ± 4.8
PPD	0.9 ± 0.22^*	4.6 ± 2.6	5.6 ± 3.2	5.8 ± 4.4	5.2 ± 2.4
PPD + rIL-12	7.4 ± 2.4^**	5.6 ± 2.8	6.1 ± 3.6	5.7 ± 2.9	6.2 ± 1.8
BCG	8.4 ± 5.10	12.3 ± 4.7	11.6 ± 6.4	12.8 ± 7.2	10 ± 7.4
BCG + rIL-12	10.6 ± 2.3	14.6 ± 6.8	22 ± 9.6	8.9 ± 3.2	11.5 ± 3

*Significant depression (p < 0.001) compared to controls; **Significant elevation (p < 0.001) by rIL-12 pre-treatment of PBMC in PPD stimulated PBMC culture compared to untreated PPD stimulated PBMC culture.