Table 1: Key Studies that
Investigated NRTI-Associated Macrocytosis.
|
Authors |
Study
design |
Population
(n) |
NRTI(s)
assessed (n) |
NRTI(s)
Associated with Macrocytosis |
|
|
Romanelli
et al. [4] |
Retrospective,
single-center chart review |
HIV-infected
patients (164) |
AZT
(71) |
AZT |
|
|
Genné
et al. [6] |
Retrospective,
single-center cohort study |
Cases
with macrocytosis (30) |
ddI
(4/30) |
d4T |
|
|
Controls
without macrocytosis (60) |
d4T
(28/30) |
||||
|
Eyer-Silva
et al. [11] |
Retrospective,
single-center study |
A:
AZT- naïve (81) |
d4T
(115) |
d4T |
|
|
B:
AZT-experienced (34) |
|||||
|
All
Patients on d4T |
|||||
|
Khawcharoenporn
et al. [12] |
Retrospective,
single-center study |
60
HIV-infected patients not on AZT or d4T |
3TC
(n/r) |
3TC |
|
|
ABC
(n/r) |
|||||
|
TDF
(n/r) |
|||||
|
Petersen
et al. [14] |
Retrospective,
multicenter chart review |
590
HIV-infected patients |
All
AZT (527) |
AZT |
|
|
AZT
monotherapy (412) |
d4T |
||||
|
All
d4T (40) |
3TC |
||||
|
All
3TC (139) |
|
||||
|
All
ddI (28) |
|
||||
|
ddI monotherapy (11) |
|
||||
|
Diop
et al. [15] |
Retrospective,
transversal study |
112
HIV-infected patients |
3TC
(150) |
AZT |
|
|
d4T
(21) |
d4T |
||||
|
AZT
(83) |
3TC |
||||
|
ABC
(84) |
|
||||
|
TDF
(60) |
|
||||
|
ddI
(33) |
|
||||
|
Steele
et al. [17] |
Retrospective,
single-center chart review |
61
HIV-infected patients |
3TC
(8) |
AZT |
|
|
AZT
(30) |
d4T |
||||
|
d4T
(41) |
3TC |
||||
|
Volberding
et al. [22] |
Double-blind,
multicenter, placebo controlled trial |
1637
HIV-infected patients |
AZT
(1090) |
AZT |
|
|
Placebo
(547) |
|||||
|
Richman
et al. [27] |
Double-blinded,
placebo controlled trial |
278
HIV-infected patients |
AZT
(143) |
AZT |
|
|
Placebo
(135) |
|||||
|
Ahmad
et al. [33] |
Retrospective,
single-center case series |
17
HIV-infected patients |
d4T |
d4T |
|
|
Martin
et al. [31] |
Retrospective,
single-center chart review |
91
HIV-infected patients |
d4T |
d4T |