Table 2: Variables associated with survival of HIV-infected patients with hepatocellular carcinoma by Cox regression analysis

Univariate Cox regression analysis Multivariate Cox regression analysis
Variable HR 95% CI P HR 95% CI P
CDC category C 0.76 0.38-1.53 0.44
cART 0.75 0.27-2.14 0.59
CD4 cells (%) 0.99 0.95-1.02 0.42
Detectable HIV-RNA 1.89 0.97-3.67 0.06 0.72 0.34-1.49 0.37
HCV infection 1.16 0.35-3.80 0.81
Child-Pugh (A vs. BC) 0.87 0.45-1.69 0.68
Decompensation 0.87 0.45-1.67 0.68
MELD score 1.09 1.01-1.67 < 0.01 1.18 1.08-1.29 < 0.001
Alcohol consumption 0.65 0.28-1.48 0.30
BCLC (CD vs. 0AB) 16.89 6.02-47.43 < 0.001 9.97 2.58-38.52 0.001
AFP > 200 ng/ml 3.58 1.83-6.99 < 0.001 5.52 2.27-13.45 < 0.001
Any treatment 0.13 0.06-0.29 < 0.001 0.25 0.08-0.77 0.016
Screening of HCC 0.69 0.35-1.33 0.26
Diagnosis after 2006 0.64 0.33-1.22 0.17


Abbreviations: cART, combination antiretroviral therapy; MELD, Model for End-stage Liver Disease; BCLC, Barcelona-CliŽnic Liver Cancer staging system; AFP, alpha-fetoprotein; HCC, hepatocellular carcinoma.