Table 2: Pharmacokinetic profile of subjects and cyclosporine dose.
|
Stable Patients (n = 10) |
Patients with CAD (n = 5) |
Cyclosporine dosage (mg/kg/d) |
4.6 ± 1.9 |
4.4 ± 2.5 |
C0 (ng/mL) |
73.5 ± 61.4 |
132.5 ± 54.8 |
C2 (ng/mL) AUC (ng.h/mL)* |
501.1 ± 242.4 2868 ± 1058 |
692.1 ± 118.2 4380 ± 542 |
Acute rejection attacks (n)* |
2/10 |
4/5 |
Glomerular filtration rate (mL/min/1.73 m2) |
84 ± 29 |
76 ± 51 |
Posttransplant duration (mo) |
20.4 ± 22.8 |
34.1 ± 21.5 |
*P < 0.05