Table 5: ISHLT recommendations for anti-viral prophylaxis and pre-emptive therapies [107].

Donor/Recipient cytomegalovirus status

Donor status positive

Donor status negative

Recipient status positive

Oral vanganciclovir for 3 months

or

IV ganciclovir for 1-3 months

or

Monitor viral load with nucleic acid testing or cytomegalovirusantigenemia assay, and if required, initiate preemptive therapy with IV ganciclovir or oral valganciclovir

Oral valganciclovir for 3 months

or

IV ganciclovir for 1-3 months

or

Monitor viral load with nucleic acid testing or cytomegalovirusantigenemia assay, and if required, initiate preemptive therapy with IV ganciclovir or oral valganciclovir

Recipient status negative

Oral vanganciclovir for 3 months

or

IV ganciclovir for 1-3 months

Prophylaxis with acyclovir