Table 1: Composition of preservation solutions.
|
|
Modified
STS |
Celsior® |
|
Electrolytes |
|
|
|
Na+ |
149
mmol/L |
100
mmol/L |
|
K+ |
19
mmol/L |
15
mmol/L |
|
Ca2+ |
2.0
mmol/L |
0.25
mmol/L |
|
Mg2+ |
19
mmol/L |
13
mmol/L |
|
Cl- |
120
mmol/L |
41.5
mmol/L |
|
|
|
|
|
Metabolic substrates |
|
|
|
Glucose |
39
mmol/L |
0 |
|
Aspartate Glutamate Antioxidants |
24
mmol/L 0 |
0 20
mmol/L |
|
Glutathione |
0 |
3
mmol/l |
|
Osmotic agents |
|
|
|
Lactobionate |
0 |
80
mmol/L |
|
Mannitol |
0 |
60
mmol/L |
|
|
|
|
|
Acid-base buffers |
|
|
|
Histidine |
0 |
30
mmol/L |
|
Bicarbonate |
28
mmol/L |
0 |
|
|
|
|
|
Osmolarity |
400
mOsm/L |
360
mOsm/L |
The composition of St. Thomas’ Solution (STS)
and Celsior used are outlined above. Glyceryl trinitrate (GTN, 0.1 g/L)
and erythropoietin (EPO, 5000 U/L) were added to Celsior
for the groups of donor hearts arrested and stored with supplemented Celsior (Celsior+EPO+GTN).