Table 5: Pathological incidence in male Sprague-Dawley rats after repeated iv injections of DINP and other test materials for 4 wk.
Pathological change type | Pathological incidence (n/n) | ||||
Control | 125 mg/kg DINP | 250 mg/kg DINP | 500 mg/kg DINP | 500 mg/kg DEHP | |
Tiny hepatic granulomas | 0/10 | 0/10 | 0/10 | 2/10 | 2/10 |
Liver header lymphocyte infiltration | 0/10 | 0/10 | 0/10 | 3/10 | 4/9 |
Liver vacuolation | 0/10 | 0/10 | 0/10 | 0/10 | 4/9 |
Small local hepatic necrosis | 0/10 | 0/10 | 0/10 | 1/10 | 4/9 |
Regional lymphocytes infiltration in kidney | 1/10 | 1/10 | 1/10 | 1/10 | 4/9 |
Small local nephritic necrosis | 0/10 | 0/10 | 0/10 | 0/10 | 4/9 |
Testis local seminiferous tubule epithelium spermatocyte and spermatid disappearance | 0/10 | 0/10 | 0/10 | 1/10 | 4/9 |