Table 4: Clinical biochemistry in male Sprague-Dawley rats when administered DINP and other test materials repeatedly for 4 wk.
Parameter | Group | ||||
Control | 125 mg/kg DINP | 250 mg/kg DINP | 500 mg/kg DINP | 500 mg/kg DEHP | |
ALT (U/L) | 39.7 ± 4.9 | 44.8 ± 8.7 | 41.0 ± 8.64 | 39.8 ± 14.1 | 37.2 ± 3.8 |
AST (U/L) | 119.3 ± 24.8 | 124.6 ± 27.1 | 127.6 ± 16.4 | 118.2 ± 20.0 | 133.3 ± 9.1 |
ALP (U/L) | 192.5 ± 24.0 | 178.5 ± 27.2 | 204.8 ± 17.3 | 184.4 ± 34.2 | 171.7 ± 35.3 |
TP (g/L) | 60.0 ± 2.2 | 59.9 ± 2.2 | 62.3 ± 2.7 | 61.1 ± 1.8 | 63.3 ± 2.5** |
Alb (g/L) | 20.7 ± 1.7 | 20.5 ± 1.6 | 20.5 ± 2.5 | 20.0 ± 1.4 | 19.0 ± 1.1* |
Tchol (mmol/L) | 0.97 ± 0.18 | 0.96 ± 0.18 | 0.88 ± 0.18 | 1.01 ± 0.16 | 1.02 ± 0.18 |
BUN (mmol/L) | 6.70 ± 0.90 | 7.36 ± 0.79 | 6.59 ± 1.38 | 6.30 ± 0.97 | 7.43 ± 0.59 |
Ca (mmol/L) | 2.25 ± 0.06 | 2.11 ± 0.06** | 2.21 ± 0.09 | 2.23 ± 0.05 | 2.20 ± 0.06 |
Tbili (umol/L) | 0.42 ± 0.33 | 0.40 ± 0.18 | 0.50 ± 0.34 | 0.70 ± 0.37 | 0.25 ± 0.25 |
Glu (mmol/L) | 8.63 ± 0.97 | 10.82 ± 1.68* | 7.79 ± 0.39 | 8.24 ± 0.94 | 9.75 ± 2.02 |
TG (mmol/L) | 0.31 ± 0.12 | 0.32 ± 0.08 | 0.27 ± 0.07 | 0.33 ± 0.09 | 0.48 ± 0.07** |
Crea (umol/L) | 30.82 ± 3.68 | 34.03 ± 4.33 | 26.61 ± 3.84 | 30.29 ± 5.60 | 33.96 ± 3.90 |
CK (U/L) | 927.2 ± 348.8 | 1278.2 ± 236.8 | 1131.6 ± 180.6 | 1082.3 ± 287.8 | 1727.5 ± 371.7** |
Na (mmol/L) | 139.8 ± 1.17 | 138.8 ± 1.45 | 140.2 ± 2.15 | 140.2 ± 1.29 | 140.1 ± 0.83 |
K (mmol/L) | 4.94 ± 0.27 | 4.83 ± 0.30 | 4.96 ± 0.34 | 4.78 ± 0.39 | 4.87 ± 0.28 |
Cl (mmol/L) | 107.6 ± 1.9 | 107.5 ± 1.9 | 107.9 ± 1.3 | 106.9 ± 1.9 | 106.8 ± 1.6 |
LDH (U/L) | 572.2 ± 239.2 | 706.8 ± 191.3 | 703.5 ± 156.0 | 742.4 ± 272.9 | 675.8 ± 113.6 |
Data are mean ± SD (n = 9-10); *P < 0.05; **P < 0.01; Compared with the control group.