Table 1: Establishing the RfDs and RfCs submitting to the rounding analysis.
Basis for elimination |
Number of chemicals removed from an initial 2019 RSL Table universe of 660 oral RfDs |
Number of chemicals removed from an initial 2019 RSL Table universe of 232 inhalation RfCs |
Lower position in peer-review hierarchy |
309 |
141 |
Benchmark dose methodology used |
44 |
26 |
Lacking adverse effect |
5 |
0 |
Human as test subject |
15 |
8 |
Non-mammal test subject |
2 |
0 |
Other1 |
40 |
11 |
Sum of chemicals removed |
415 |
186 |
Chemicals retained for analysis |
245 |
46 |
1Includes designations such as 'archived', 'not evaluated', 'not available at this time', and 'withdrawn'.