Table 1: Establishing the RfDs and RfCs submitting to the rounding analysis.

Basis for elimination

Number of chemicals removed from an initial 2019 RSL Table universe of 660 oral RfDs

Number of chemicals removed from an initial 2019 RSL Table universe of 232 inhalation RfCs

Lower position in peer-review hierarchy

309

141

Benchmark dose methodology used

 44

26

Lacking adverse effect

 5

0

Human as test subject

15

8

Non-mammal test subject

 2

0

Other1

40

11

Sum of chemicals removed

415

186

Chemicals retained for analysis

245

46

1Includes designations such as 'archived', 'not evaluated', 'not available at this time', and 'withdrawn'.