Table 1: Characteristics of the included studies.

Author (Year)

Study design

Population (N)

Age group

Primary outcome(s)

van de Weg, et al. (2014) [16]

Case-control

Obs-control

Adults

Ang-2, sVEGFR-2, MMP-2

Mapalagamage, et al. (2020) [17]

Observational cohort

DF, DHF, HC

Mixed (adults)

Ang-1, Ang-2, Ang-2/1 ratio

Michels, et al. (2011)

Prospective cohort

Children: DHF n = 43; DSS n = 28

Children

Ang-1, Ang-2

Michels, et al. (2024)

Pediatric

DF = 30, DHF = 30, Severe = 23

Pediatric

Syndecan-1, Ang-1, Ang-2A2, Ferritin, IL-6

Mangione, et al. (2017) [18]

Observational

DF n = 6, DHF n = 18, DSS n = 33

Dengue

VCAM-1, VEGF-A, IL-8

Yacoub, et al. (2017) [3]

Prospective

Dengue n = 52

Adults

RHI-L-arginine, Arginase-1

Conroy, et al. (2015)

Nested case-control

DF n = 65; DHF/DSS n = 46; HC n = 15

Adults

sICAM-1

Khaing, et al. (2025)

Prospective cohort

Dengue n = 48; HC n = 192

Adults

ANGPTL4

Nolitriani, (2021) [19]

Cross-sectional

DF vs DHF children

Pediatric

Syndecan-1, VCAM-1

Liap, et al. (2015)

Observational cohort

DF vs DSS adults

Adults

VCAM-1