Table 2: Antileishmanial activity and cytotoxicity of aryl-substituted imidazoles.
Compounds |
L. infantum [1] IC50 ± SD (μM) |
L. amazonensis IC50 ± SD (μM) |
BALB/c mice Macrophages CC50 ± SD (μM) |
SI |
1 |
1.02 ± 0.02 |
6.98 ± 0.8 |
178.09 ± 3.5 |
26 |
2 |
> 64.0 |
8.94 ± 1.0 |
69.32 ± 1.5 |
8 |
3 |
- |
16.22 ± 0.3 |
126.07 ± 5.2 |
8 |
4 |
10.23 ± 1.16 |
10.35 ± 1.2 |
178.27 ± 0.9 |
17 |
5 |
4.11 ± 0.51 |
15.94 ± 2.4 |
11.90 ± 0.8 |
1 |
6 |
1.99 ± 0.19 |
> 46.35 |
41.48 ± 0.5 |
1 |
7 |
40.89 ± 6.21 |
6.72 ± 0.6 |
41.48 ± 0.6 |
6 |
8 |
16.44 ± 1.77 |
26.27 ± 0.7 |
30.77 ± 0.8 |
1 |
9 |
4.07 ± 0.42 |
31.52 ± 0.2 |
25.63 ± 0.4 |
1 |
Ref. drug |
10.07 ± 4.23 |
0.03 ± 0.006 |
6.16 ± 0.5 |
193 |
IC50: concentration of compound that caused 50% of inhibition growth; SD: Standard Deviation.
Ref. drug: Miltefosine for L. infantum; Amphotericin B for L. amazonensis [15].