Table 1: Therapeutic application of oral MSCs

DPSCs These cells seem to be of great importance concerning periodontal regeneration as well as bone and dentin regeneration. However, further work on the subject needs to be developed [23,52,53]
On the other hand, they have been able to generate a dentin pulp-like complex [11,16,53].
PDLSCs These stem cells seem to be capable of generating bone, cementum, periodontal ligament-like structures and to increase periodontal regeneration [16,52]. When compared to other mesenchymal stem cells they appear to be more indicated when periodontal regeneration is intended [11,52].
SHEDs This group of stem cells are believed to be a valuable alternative when periodontal regeneration is intended and also demonstrate the ability to reconstitute a dentin pulp-like complex [11,16,52,53].
Moreover, SHED have shown bone regenerative capacity [16,23,53].
SCAPs These stem cells demonstrated positive results in what concerns the formation of dentin pulp-like complex [11,16,23,54].
Associated with PDLSCs, SCAPs were able to form a root-like structure when seeded onto hydroxyapatite-based scaffolds and implanted in pig jaws [52,54].
DFPCs The micro-environments where this stem cells are implanted have great importance to determine which tissues they are capable of forming (e.g. DFPCs implanted in the non-mineralized omental pocket contributed to dentin regeneration; DFPCs implanted in the highly mineralized skull contributed to matrix formation; DFPCs implanted in the alveolar fossa contributed to the formation of root like tissues with a pulp-dentin complex and a periodontal ligament connecting a cementum-like layer to host alveolar bone). Another important information provided by these studies is that DFPCs demonstrated high potential towards tooth roots regeneration [52].
Moreover, this group of stem cells is also capable of generating a bone/cementum-like tissue [16].