Table 4: Cohort study: Adjusted association of depression/anxiety and COPD exacerbation.

Event	Odds Ratio	95% CI	IRR	95% CI
Moderate Exacerbation	1.54	(1.42-1.67)	1.44	(1.34-1.55)
Severe Exacerbation	1.82	(1.54-2.16)	1.82	(1.53-2.15)

IRR: Incidence Rate Ratio; 95% CI, 95% Confidence Intervals;

Both the logistic regression (OR) and the negative binomial model (IRR) adjusted for sex, age, region, race;

Charlson score, use of COPD-related medications, and moderate and severe exacerbations in the baseline period.