Table 3: Comparison between patients with early versus delayed therapy for
moderate-severe community-acquired pneumonia (CAP)
|
Characteristic |
Patients with time to first dose of appropriate
antibiotic therapy ≤ 4 hours since triage (n = 83) |
Patients with time to first dose of appropriate
antibiotic therapy > 4 hours since
triage (n = 73) |
p-value |
|
Age
(years)
|
73.30
± 11.60 |
75.56
± 9.70 |
0.19 |
|
Gender |
|
|
0.26 |
|
Male |
48
(57.83%) |
35
(47.95%) |
|
|
Female |
35
(42.17%) |
38
(52.05%) |
|
|
Co-morbid
Conditions |
|
|
|
|
Chronic
heart disease
|
69
(83.13%) |
63
(86.30%) |
0.66 |
|
Chronic
lung disease
|
31
(37.35%) |
31
(42.47%) |
0.62 |
|
Cancer |
16
(19.28%) |
26
(35.62%) |
0.03 |
|
Neurologic
disease |
22
(26.51%) |
24
(32.88%) |
0.48 |
|
Chronic
renal disease |
24
(28.92%) |
20(27.40%) |
0.86 |
|
Patients
from LTCF |
15
(18.07%) |
16
(21.92%) |
0.56 |
|
Systemic
steroids use |
18
(21.69%) |
23
(31.15%) |
0.20 |
|
Duration
of symptoms before presentation (days) |
4.27
± 3.85 |
5.90
± 7.02 |
0.12 |
|
Hospitalization
in last 90 days |
15
(18.29%) |
20
(27.40%) |
0.19 |
|
Weekend
admission |
28
(33.73%) |
21
(28.77%) |
0.61 |
|
Time
seen by physician since time of triage (hours) |
0.64
± 0.55 |
1.37
± 1.64 |
0.003 |
|
Duration
of antibiotics(days) |
10.93 ± 4.32 |
11.18 ± 4.95 |
0.74 |
|
Length
of hospital stay (days) |
9.92
± 9.71 |
11.12
± 11.42 |
0.48 |
|
Patients
on macrolide |
45
(54.22%) |
35
(47.95%) |
0.52 |
|
Patients on fluoroquinlones |
24
(28.92%) |
19
(26.03%) |
0.72 |
|
Positive
culture (respiratory or blood) |
9
(10.84%) |
4
(5.48%) |
0.14 |
|
Complications |
44
(53.01%) |
37
(50.65%) |
0.87 |
|
Complications
within 24 hours of admission |
28
(33.73%) |
26
(35.62%) |
0.87 |
|
Complications
after 24 of admission(hours) |
26
(31.33%) |
33
(45.21%) |
0.10 |
|
Cardiac
complications |
7
(8.43%) |
6
(8.22%) |
1.000 |
|
Death |
8
(9.64%) |
23
(31.31%) |
0.001 |
Data expressed as mean ±
SD or frequency and percentage as indicated.