History and mode of administration of D-PA in neonates in Debrecen NICU (in NHBI the drug was used 3 × 100 mg/kg bw. daily for 1-7 days, IV or PO depending on TSB).

Table 1: History and mode of administration of D-PA in neonates in Debrecen NICU (in NHBI the drug was used 3 × 100 mg/kg bw. daily for 1-7 days, IV or PO depending on TSB).

	First period (1973-1979)	Second period (1979-1980)	Third/fourth period (1981-1982)
Dosage and administration	3 × 100 mg/kg bw. IV for 1-7 days	3 × 100 mg/kg bw IV for 3 days	3 × 100 mg/kg bw IV for 3 days + 50 mg/kg IV for 2 weeks
Aim of the IV drug administration	only NHBI	all prematures < 1500 g bw	all prematures < 1500 g bw