Table 1: The endogenous intoxication (EI) in infants.
|
The
main risk factors of EI |
The
main factors of intoxication |
|
1. The oxidative stress
(ischemia, hypoxia, shock) |
1. The accumulation of oxygen
free radicals |
|
2. The anoxic damage of the mitochondria |
2. The toxic modification of
proteins, DNA and RNA |
|
3. The reduction of toxins’
biotransformation in the liver |
3. The depletion of antioxidant
system |
|
4. The elimination’ reduction
of toxins in the kidneys |
4. The damages of the lipids
cellular membrane by IBS. The increase of lipids’ inflammatory mediators. |
|
5. Drug intoxication |
5. Violation of cellular
calcium homeostasis |
|
6. Intoxication be metals |
6. Reduction of bioenergy
(reduction of ATP concentration and increase of lactate) |
|
7. The excessive accumulation
of metabolites |
7. Fermentopathy |
|
8. Natural and industrial
xenobiotics |
8. The accumulation of
homocysteine and uric acid |
|
9. Genetic abnormalities |
9. The accumulation of average
molecules |
|
- |
10. The activation of proteins
of an acute inflammation phase |
|
- |
11. Autoimmune reactions |
|
- |
12. Recycling of toxicants in
kidney |
|
|
Abbreviations
DNA: Deoxyribonucleic Acid; RNA: Ribonucleic Acid; ATP:
Adenosine Triphosphate Acid