Table 2: Median concentrations (pg/ml), minima and
maxima of cytokines in patients with oJIA, sJIA and control subjects.
Recorded
data (ELISA) [median
(range) pg/ml] |
Patients
oligoarticular arthritis [n] 10 |
Patients
systemic arthritis [n] 10 |
controls
[n] 25 |
IL-1β unstimulated |
34.0
(0-141.19) |
76.04
(0 -719.15) |
98.01
(0 -675.18) |
IL-6 unstimulated |
92.0
(0-2626.06) |
53.91
(0-14819.80) |
349.99
(0-40579.92) |
IL-10 unstimulated |
1.19
(0-4.75) |
0.1
(0.1-27.42) |
0.1
(0.1-179.28) |
TNF-α unstimulated |
9.83
(0-32.26) |
136.57
(0-2130.29) |
64.96
(51.23-1065.6) |
IFN-γ unstimulated |
2.24
(0-9.24) |
0.1
(0-0.1) |
0.1
(0.1-22.59) |
IL-1β LPS stimulated |
11001.26
(4713.39-27778.74) |
1659.40
(365.85-7771.52) |
1176.65
(0-2324.18) |
IL-6 LPS stimulated |
12368.07
(8488.45-25293.46) |
19684.29
(4620.57-29113.37) |
12524.96
(2418.22-47511.88) |
IL-10 LPS stimulated |
789.88
(539.3-5786.66) |
208.87
(0.1-802.3) |
353.46
(3.58-663.24) |
TNF-α LPS stimulated |
416.69
(81.71-6767.84) |
1810.98
(373.02-7873.45) |
1035.95
(405.05-5864.38) |
IFN-γ LPS stimulated |
63.33
(7.96-368.58) |
0.1
(0.1-260.99) |
8.90
(0.1-259.50) |
IL-1β LPS & anakinra |
8755.14 (3657.02-16271.48) |
1152.88
(378.32-3152.67) |
1002.11
(134.10-1605.97) |
IL-6 LPS & anakinra |
9687.29 (4724.48-36326.38) |
7595.17
(1384.23-32177.63) |
5102.66
(468.64-1489779.84) |
IL-10 LPS & anakinra
|
425.23 (119.11-3404.71) |
15.44
(0-250.44) |
72.74
(0 -212.0) |
TNF-α LPS & anakinra
|
466.33 (36.16-5806.20) |
566.28
(0-3824.89) |
296.02
(0-1716.59) |
IFN-γ LPS & anakinra
|
2.45 (0-177) |
0.1
(0-14) |
0.1
(0-22.13) |
IL-1β LPS & adalimumab |
10225.845
(4424.78-25403.25) |
1973.0
(680.54-4216.76) |
531.11
(136.37-2583.18) |
IL-6 LPS & adalimumab |
12474.815
(6037.93-22902.13) |
12272.84 (3068.83-32177.63) |
3944.91 (1870.02-47511.88) |
IL-10 LPS & adalimumab |
676.965 (363.6-4341.47) |
97.766 (0-455.72) |
38.62 (0-480.76) |
TNF-α LPS & adalimumab |
3.035 (0-22.04) |
6.14
(0-26.45) |
13.22
(0-746.46) |
IFN-γ LPS & adalimumab |
19.085 (7.27-261.67) |
0.1
(0-29.44) |
0.1
(0-11.80) |