Cases of pediatric necrotizing AAP treated without octreotide, reported in literature..

Table 2: Cases of pediatric necrotizing AAP treated without octreotide, reported in literature.

References	Age/sex	Type of asparaginase/ treatment phase	Complications	Surgery	Outcome
Raizner et al. [4]	11.5 y/M	L-asp/NR	Pleural effusions, ascites, respiratory distress, pseudocyst, diabetes, exocrine insufficiency	No	Recovery
Raizner et al. [4]	17.8 y/M	L-asp/NR	Pleural effusions, ascites, respiratory distress, hyperglycemia, DIC	No	Recovery
Sadoff et al. [24]	5 y/M	L-asp/Induction	Sepsis, pseudocyst, retroperitoneal necrosis	No	Died
Sadoff et al. [25]	5 y/M	PEG-asp/Induction	Infected PFC and pseudocyst	Yes	Recovery

M: Male; L-asp: L-Asparaginase; NR: Not Reported; DIC: Disseminated Intravascular Coagulation; PFC: (peri)- Pancreatic Fluid Collection; Y: Years