Table 1:
Results of serum, fecal, liver and colonic samples analysis from different
experimental groups.
|
CN |
CNDMH |
CHOL |
CHOLDMH |
Initial weight (g) |
180 ± 6 |
166 ± 7 |
147 ± 7 |
152 ± 3 |
Final weight (g) |
314 ± 9 |
297 ± 16 |
291 ± 16 |
296 ± 7 |
Gain weight (g) |
134 ± 7 |
149 ± 7 |
146 ± 8 |
144 ± 7 |
Triglycerides (mg/dl) |
82 ± 4 |
59 ± 4* |
85 ± 7 |
58 ± 5* |
Total cholesterol
(mg/dl) |
128 ± 8 |
123 ± 8 |
111 ± 5 |
105 ± 7 |
HDL-cholesterol (mg/dl) |
36 ± 3 |
37 ± 2 |
36 ± 2 |
34 ± 1 |
Hepatic cholesterol (mg/dl) |
31 ± 2 |
37 ± 3 |
35 ± 3 |
33 ± 2 |
Fecal Cholesterol (mg/dl) |
34 ± 5 |
24 ± 3 |
66 ± 3** |
69 ± 5++ |
Bifidobacteria (UFC/g) |
4.35 ± 3.39×1010 |
8.37 ± 3.10×1010 |
9.39 ± 3.64×1010 |
4.48 ± 2.81×1010 |
Fecal pH |
7.0 ± 0.3 |
7.2 ± 0.3 |
6.5 ± 0.1 |
7.1 ± 0.3* |
PCNA (%) |
5.76 ± 0.91 |
16.20 ± 1.70 |
8.44 ± 0.23 |
20.48 ± 0.37++ |
ACF/field |
0 |
0.68 ± 0.16 |
0 |
0.41 ± 0.50 |
(AC/ACF) |
0 |
2.52 ± 0.33 |
0 |
2.11 ± 0.21 |
Results are expressed as mean ± standard
error. * p < 0.01, compared to the group treated with the respective diet
without DMH; **compared to CN group; ++compared to CNDMH group. Standard diet
(CN); standard diet + cholesterol 1% (CHOL); standard diet + DMH (CNDMH) and
standard diet + cholesterol 1%+ DMH (CHOLDMH). PCNA (proliferating cell nuclear
antigen), ACF (Aberrant crypt foci) and AC/ACF (aberrant crypt/aberrant crypt
foci).