Pathologists substantially agree on grading specimens, moderately agree on the presence of tumor and LVSI. Staining does not improve LVSI agreement, Krippendorf's α with 95% confidence interval in brackets.

Table 1: Pathologists substantially agree on grading specimens, moderately agree on the presence of tumor and LVSI. Staining does not improve LVSI agreement, Krippendorf's α with 95% confidence interval in brackets.

	Krippendorf’s α
Grade	0.700 [0.612 to 0.778]
Presence of Tumor	0.540 [0.426 to 0.631]
LVSI (with staining)	0.469 [0.319 to 0.589]
LVSI (without staining)	0.503 [0.351 to 0.631]