Table 1A: Demographic, clinical and histological characteristics of patients with Langerhans cell histiocytosis in vulva
Table 1A: Demographic, clinical and histological characteristics of patients with Langerhans cell histiocytosis in vulva |
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Author |
Age (Years) |
Type of skin lesion |
Affected site |
Immunohistochemistry exam |
Systemic commitment |
Treatment |
Response |
Outcome (months) |
Shah PR et al [1] |
54 |
Papule |
Labia majora |
S100 (+) CD1a (+) |
No |
Thalidomide + Tacrolimus + MTX |
NI |
NI |
Jorgensen EM et al [2] |
8 |
Ulcer |
Vulva |
S100 (+) CD1a (+) |
Osseous |
CT(Vinblastin) + PREDNIS |
CR |
NED (12) |
Wieland R et al [3] |
26 |
Papule |
Labia minora |
S100 (+) CD1a (+) |
No |
Local excision |
CR |
NED (23) |
|
67 |
Vesicle |
Labia majora |
CD1a (+) |
No |
Local excision + hydrocortisone cream |
CR |
NED (130) |
|
31 |
Papule |
Cervix |
NI |
No |
Hysterectomy |
CR |
NED (54) |
Nic DE et al [4] |
16 |
Ulcer |
Vulva |
S100 (+) CD1a (+) |
Pituitary |
CT(Cytarabine) + PREDNIS |
NI |
NI |
Ruiz BJ et al [5] |
56 |
Plaque |
Vulva |
S100 (+) CD1a (+) |
No |
Thalidomide + Clobetazol |
CR |
NED (2) |
Zudaire T et al [6] |
59 |
Plaque/ Ulcer |
Labia minora |
S100 (+) CD1a (+) |
Osseous/ Skin |
CT(Cytarabine) |
NI |
NI |
Baser S et al [7] |
3 |
Plaque |
Vulva |
NI |
Osseous/Liver |
CT(Vinblastine) + PREDNIS |
CR |
NED (8) |
Gordon MS et al [8] |
22 |
NI |
Vulva |
S100(+) CD1a (+) CD68(+) |
Pituitary |
PREDNIS |
NI |
NI |
Martínez CD et al [9] |
26 |
Ulcer |
Vulva |
S100(+) CD1a (+) CD68 (+) Vimentin (+) |
Lung |
Local excision + topical corticosteroid |
CR |
NED (96) |
Ikeya S et al [10] |
20 |
Nodules |
Vulva |
S100(+) CD1a (+) Birbeck Granules |
Pituitary |
Cladribine + PREDNIS + |
NI |
NI |
Pedrosa AFB et al [11] |
43 |
Ulcer |
Clitoris |
S100 (+) CD1a (+) |
Skin/ Gingiva |
PREDNIS |
NI |
NI |
Rasool S et al [12] |
76 |
Plaque |
Labia minora/ Clitoris |
S 100(+) CD1a (+) CD68(+) Birbeck Granules (+) |
Skin |
Topical corticosteroid |
NI |
NI |
Sun N et al [13] |
28 |
Ulcer |
Vulva |
S100(+) CD1a (+) Vimentin (+) |
No |
Interferon + PREDNIS + MTX |
CR |
NED (18) |
Khoummane N et al [14] |
47 |
NI |
Vulva |
S100 (+) CD1a (+) |
No |
Local excision |
NI |
NI |
Singh M et al [15] |
50 |
Ulcer |
Vulva |
S100 (+) CD1a (+) |
No |
RT + Thalidomide |
NI |
NI |
Ibrahim I et al [16] |
33 |
Nodules |
Vulva |
NI |
No |
Radical vulvectomy + RT + Thalidomide + Lenalidomide |
NI |
REC (NI) |
El Fekih N et al [17] |
20 |
Ulcer |
Vulva |
S100 (+) CD1a (+) |
Osseous/Pituitary |
RT + topical corticosteroid |
NI |
NI |
Ibrahim IF et al [18] |
43 |
Nodules |
Vulva |
NI |
No |
Local excision + RT + Thalidomide + Lenalidomide |
NI |
REC (NI) |
Chang JC et al[19] |
68 |
Plaque |
Labia majora |
S100 (+) CD1a (+) |
No |
Topical corticosteroid |
CR |
NED (6) |
EL-Safadi S et al[20] |
59 |
Ulcer |
Vulva |
S100 (+) CD1a (+) |
No |
Radical Vulvectomy + RT + MTX +Thalidomide |
NI |
NED (31) |
Jiang W et al[21] |
46 |
Papule |
Labia minora |
S100(+) CD1a (+) Vimentin (+) |
No |
Local excision + CT(Vinblastin) + PREDNIS |
CR |
NED (40) |
|
40 |
Ulcer |
Labia majora |
S100(+) CD1a (+) Vimentin (+) |
No |
Local excision + CT(Vinblastin) + PREDNIS |
CR |
NED (36) |
|
23 |
Plaque |
Cervix |
S100(+) CD1a (+) Vimentin (+) |
No |
Thalidomide + CT (Vinblastin) + PREDNIS + Hysterectomy |
CR |
NED (12) |
Márques F et al[22] |
1 |
Condyloma |
Perineum |
S100 (+) CD1a (+) |
No |
CT (Vinblastin) + PREDNIS |
CR |
REC (6) |
Fernández L.B et al [23] |
60 |
Plaque |
Vulva |
S100 (+) CD1a (+) |
Skin |
Dexamethasone + Thalidomide |
VR |
NED (NI) |
Foley S et al [24] |
62 |
Nodule |
Labiaminora |
S100 (+) CD1a (+) |
No |
Clobetazol propionate |
CR |
NED (36) |
Simons M et al[25] |
33 |
Condyloma |
Labia majora |
S100 (+) CD1a (+) Vimentina (+) |
No |
Local excision + Tacrolimus + RT |
CR |
REC(11) |
Brazeal T et al[26] |
65 |
Rash |
Vulva |
S 100(+) CD1a (+) CD68(-) |
Skin/ Lungs |
NI |
NI |
NI |
NED: No evidence of disease, NI: No information; NR: No response; REC: Recurrent; CT: Chemotherapy; PREDNIS: Prednisolone; RT: Radiotherapy; MTX: Methotrexate |
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