Table 2: Data from the literature review and own patients with vaginal cancers associated with genital prolapsed.
|
Author |
Year of Publication |
Age at initial diagnosis |
Histology |
FIGO Stage |
T |
N |
M |
G |
PFS |
Follow up time in months |
died of tumor |
Surgery |
Radio therapy |
Radio chemo therapy |
chemo therapy |
Stage of prolapse |
Pessary |
veginal mesh |
Uro/Gyn previous diagnoses |
immunio- suppressive diagnoses |
immunio- suppressive medication |
|
This study |
|
76 |
sc |
II |
|
0 |
0 |
1 |
|
8 |
No |
No |
No |
Yes |
No |
0 |
No |
Yes |
Yes |
No |
Yes |
|
|
|
89 |
sc |
III |
|
|
0 |
2 |
4 |
4 |
Yes |
No |
Yes |
No |
No |
4 |
No |
No |
No |
No |
No |
|
|
|
82 |
sc |
I |
1 |
|
0 |
3 |
5 |
9 |
No |
Yes |
Yes |
No |
No |
4 |
No |
No |
Yes |
No |
No |
|
|
|
81 |
sc |
IVB |
2 |
|
1 |
3 |
4 |
10 |
Yes |
Yes |
Yes |
No |
No |
4 |
No |
No |
No |
No |
No |
|
Ishibashi [22] |
2019 |
78 |
sc |
I |
|
|
0 |
|
|
3 |
|
No |
Yes |
No |
No |
4 |
No |
No |
No |
No |
No |
|
Barbarovic [23] |
2018 |
86 |
others |
I |
1 |
0 |
0 |
3 |
|
14 |
|
Yes |
No |
No |
No |
3 |
|
No |
No |
No |
No |
|
Fedus [13] |
2017 |
69 |
sc |
IVA |
|
1 |
|
|
|
|
Yes |
No |
No |
No |
No |
4 |
|
No |
No |
No |
No |
|
Sonkusare [24] |
2016 |
80 |
sc |
II |
2 |
0 |
0 |
1 |
2 |
8 |
|
Yes |
Yes |
No |
No |
4 |
|
No |
No |
No |
No |
|
Akino [18] |
2016 |
67 |
sc |
IVB |
3 |
1 |
1 |
|
4 |
4 |
Yes |
No |
No |
No |
Yes |
3 |
Yes |
No |
No |
No |
Yes |
|
Kowalski [25] |
2015 |
82 |
sc |
IVB |
|
1 |
1 |
2 |
|
4 |
Yes |
No |
No |
Yes |
No |
4 |
No |
No |
No |
No |
No |
|
Wang [26] |
2014 |
61 |
sc |
I |
1 |
|
0 |
1 |
|
48 |
|
Yes |
Yes |
No |
No |
3 |
No |
No |
No |
No |
No |
|
Moszynski [27] |
2014 |
65 |
sc |
I |
1 |
|
0 |
1 |
1 |
36 |
|
Yes |
Yes |
No |
No |
4 |
|
No |
No |
No |
No |
|
Kim [28] |
2013 |
80 |
sc |
IVB |
|
|
1 |
|
|
1 |
Yes |
No |
No |
No |
No |
3 |
No |
No |
No |
No |
No |
|
Begum [29] |
2013 |
75 |
sc |
II |
|
|
|
|
|
|
|
No |
No |
Yes |
No |
4 |
|
No |
No |
|
|
|
Kumar [30] |
2013 |
80 |
sc |
I |
1 |
0 |
0 |
1 |
|
6 |
|
Yes |
Yes |
No |
No |
3 |
|
No |
No |
|
|
|
Martin [31] |
2013 |
72 |
Sc and ad |
II |
|
|
0 |
3 |
|
|
|
No |
Yes |
No |
No |
3 |
Yes |
No |
Yes |
No |
No |
|
Acharya [32] |
2012 |
84 |
sc |
|
|
|
|
|
|
|
|
No |
Yes |
No |
No |
4 |
|
|
|
|
|
|
Cho [33] |
2011 |
75 |
sc |
III |
|
|
|
|
|
|
|
No |
yes |
No |
No |
3 |
No |
No |
Yes |
No |
No |
|
Batista [34] |
2009 |
73 |
sc |
I |
1 |
0 |
0 |
2 |
|
24 |
|
Yes |
Yes |
No |
No |
3 |
|
No |
Yes |
No |
No |
|
Gosh [35] |
2009 |
50 |
sc |
I |
1 |
0 |
0 |
2 |
|
12 |
|
Yes |
No |
No |
No |
3 |
|
No |
No |
|
|
|
Gupta [36] |
2007 |
60 |
sc |
III |
|
|
0 |
|
|
|
|
No |
No |
Yes |
No |
3 |
|
|
|
|
|
|
lavazzo [37] |
2007 |
80 |
sc |
I |
1 |
|
0 |
3 |
|
42 |
|
Yes |
Yes |
No |
No |
4 |
|
|
No |
No |
No |
|
Karateke [38] |
2006 |
68 |
sc |
II |
|
|
0 |
1 |
|
20 |
|
No |
Yes |
No |
No |
4 |
|
|
No |
|
|
|
Jain [7] |
2006 |
96 |
others |
|
|
|
|
3 |
|
|
No |
No |
No |
No |
No |
3 |
Yes |
No |
No |
|
|
|
|
|
88 |
sc |
|
|
|
|
3 |
|
|
Yes |
No |
No |
No |
No |
3 |
Yes |
no |
Yes |
|
|
|
Meier [39] |
1995 |
74 |
sc |
|
|
|
0 |
2 |
|
12 |
|
No |
No |
Yes |
No |
3 |
|
|
No |
No |
No |
|
Bemal Bastidas [40] |
1989 |
84 |
sc |
I |
1 |
|
|
1 |
|
|
|
Yes |
Yes |
No |
No |
3 |
|
|
|
|
|
|
Rao [11] |
1989 |
44 |
sc |
|
|
|
0 |
1 |
|
|
|
No |
Yes |
No |
No |
3 |
|
|
|
|
|
|
|
|
45 |
sc |
|
|
|
0 |
1 |
18 |
18 |
|
No |
Yes |
No |
No |
3 |
|
|
|
|
|
|
|
|
50 |
sc |
|
|
|
0 |
1 |
|
|
|
No |
Yes |
No |
No |
3 |
|
|
|
|
|
|
|
|
55 |
sc |
IVA |
|
|
0 |
1 |
|
|
|
No |
Yes |
No |
No |
4 |
|
|
|
|
|
|
|
|
61 |
sc |
|
|
|
0 |
1 |
|
|
|
No |
No |
No |
No |
4 |
|
|
|
|
|
|
|
|
72 |
sc |
IVB |
|
|
1 |
3 |
3 |
3 |
Yes |
No |
Yes |
No |
No |
4 |
|
|
|
||
|
Howat [41] |
1984 |
74 |
sc |
|
|
|
|
|
|
|
|
No |
Yes |
No |
No |
|
|
no |
no |
|
|
|
Gautier [42] |
1971 |
77 |
sc |
II |
|
0 |
0 |
|
|
|
|
No |
Yes |
No |
No |
1 |
Yes |
|
|
|
|
|
|
|
83 |
sc |
III |
|
|
|
|
|
|
|
No |
Yes |
No |
No |
|
Yes |
|
Yes |
|
|
|
Amalric [43] |
1970 |
85 |
sc |
|
|
|
|
|
|
|
|
No |
Yes |
No |
No |
|
Yes |
|
|
|
|
|
Lamotte [44] |
1969 |
67 |
ad |
|
|
|
|
|
|
|
|
No |
Yes |
No |
No |
|
Yes |
|
|
No |
No |
|
Russel [8] |
1961 |
55 |
|
|
|
|
|
|
|
|
|
|
|
|
Yes |
|
|
|
|
||
|
|
|
74 |
|
|
|
|
|
|
|
|
|
|
|
|
Yes |
|
|
|
|
||
|
|
|
66 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Yes |
|
|
|
|
|
|
|
|
84 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Yes |
|
|
|
|
|
|
75 |
|
|
Yes |
||||||||||||||||||
|
77 |
|
|
Yes |
||||||||||||||||||
|
Berthelsen [45] |
1957 |
83 |
sc |
I |
|
|
0 |
|
|
|
|
yes |
No |
No |
No |
4 |
|
|
Yes |
No |
No |
Histology: sc: sqamous cell carcinoma, ad: adeno carcinoma; TNM stage: T: tumour, N: nodes, M: metastasis G: grading, PFS: progression free survival in month