Table 4: Interobserver agreement.
Type of sample interpreted |
||||||
|
Cervical cytology, double staining P16/Ki67 |
Cervical biopsy, staining P16 |
Cervical cone, staining with P16 |
|||
Kappa indexa |
95%CI |
Kappa indexa |
95%CI |
Kappa indexa |
95%CI |
|
A-B |
0.77* |
0.69-0.84 |
0.83* |
0.77-0.89 |
0.81* |
0.60-1.0 |
A-C |
0.74* |
0.65-0.84 |
0.89* |
0.85-0.93 |
0.90* |
0.81-0.99 |
A-D |
0.83* |
0.77-0.89 |
----- |
----- |
----- |
----- |
B-C |
0.66* |
0.57-0.75 |
0.80* |
0.74-0.87 |
0.76* |
0.53-0.98 |
B-D |
0.75* |
0.66-0.81 |
----- |
----- |
----- |
----- |
C-D |
0.75* |
0.67-0.84 |
----- |
----- |
----- |
----- |
A: Expert Pathologist; B y C: Guatemalan Pathologists; D: Cytotechnologist; K: Weighted Kappa; CI: Confidence Interval; *P value < 0.0001.