Table 4: Interobserver agreement.

Type of sample interpreted

Cervical cytology, double staining P16/Ki67

Cervical biopsy, staining P16

Cervical cone, staining with P16

Kappa indexa

95%CI

Kappa indexa

95%CI

Kappa indexa

95%CI

A-B

0.77*

0.69-0.84

0.83*

0.77-0.89

0.81*

0.60-1.0

A-C

0.74*

0.65-0.84

0.89*

0.85-0.93

0.90*

0.81-0.99

A-D

0.83*

0.77-0.89

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B-C

0.66*

0.57-0.75

0.80*

0.74-0.87

0.76*

0.53-0.98

B-D

0.75*

0.66-0.81

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C-D

0.75*

0.67-0.84

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A: Expert Pathologist; B y C: Guatemalan Pathologists; D: Cytotechnologist; K: Weighted Kappa; CI: Confidence Interval; *P value < 0.0001.