Table 1: Inclusion and exclusion criteria.
Inclusion criteria | Exclusion criteria |
✓ Age from 18 to 80 years ✓ Some type of cancer confirmed by pathology and staged in stage III and IV. ✓ Patients who want to participate and who have no difficulty to comply with the development of the study. ✓ Must have a Karnosfsky index > 50%. ✓ Life expectancy is greater than 6 months. ✓ Minimum 4 weeks must have elapsed between the end of the last chemotherapy, radiotherapy, glucocorticoid therapy or alternatives. ✓ No history of adverse reactions to vaccines or medications. ✓ No history of allergies to medications and foods. ✓ Patients must have laboratory parameters (blood count, renal function (GFR), partial urine, fasting blood glucose, specific antigen and ACE. ✓ human chronic gonadotropin pregnancy test) negative no more than two weeks, serology VDRL, HBsAg, anti- VHC Y Elisa para VIH negatives. |
- Active bleeding or uncontrolled active infection. - Dx of HIV infection, viral hepatitis, tuberculosis or immunosuppressed patients. - Pre-existing autoimmune disease. - Psychiatric illness, cognitive disability (ability to understand information about the study) / social situation that would limit the fulfillment of the study. - Person who have participated in previous clinical studies. - Women in pregnancy and/or breastfeeding. - Men and women of childbearing age who do not use a safe method of family planning (condom with spermicide, IUD, subdermal implants, oral and/or injectable contraceptives and Pomeroy). ✓ - Consumers of psychoactive substances. |