<?xml version="1.0" encoding="UTF-8"?>

<article>
<meta-data>
<journal-meta>
<journal-name>International Journal of Oral and Dental Health</journal-name>
<journal-shortname>Int J Oral Dent Health</journal-shortname>
<journal-doi>10.23937/2469-5734</journal-doi>
<issn>2469-5734</issn>
<publisher>
<publisher-name>ClinMed International Library</publisher-name>
<publisher-location>Wilmington, USA</publisher-location>
<publisher-doi-prefix>10.23937</publisher-doi-prefix>
</publisher>
</journal-meta>
<article-meta>
<article-title>
The Simplified Pain Catastrophizing Scale (PCS-S): A Pilot Study of a Screening Tool for Orofacial Pain
</article-title>
<citation_author>Metello Neves LB</citation_author>
<article-doi>10.23937/2469-5734/1510176</article-doi>
<article-description>
The management of orofacial pain (OFP) and temporomandibular disorders (TMD) is based on the biopsychosocial model, where pain catastrophizing is a critical predictor of worse clinical outcomes. Although the 13-item Pain Catastrophizing Scale (PCS) is considered the gold standard, it is impractical in high-volume clinics, creating a gap between research and practice.
</article-description>
</article-meta>
</meta-data>
<body>
<article-type>Original Article</article-type>
<volume>12</volume>
<issue>2</issue>
<access-type>OPEN ACCESS</access-type>
<article-doi>10.23937/2469-5734/1510176</article-doi>
<article-title>
The Simplified Pain Catastrophizing Scale (PCS-S): A Pilot Study of a Screening Tool for Orofacial Pain
 
</article-title>
<Author-Group>
<aut id="aut1">
<label>Author-1</label>
<name>Leonardo Brigido Metello Neves</name>
<affiliation>
Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil
</affiliation>
<affiliation>
Department of Orofacial Pain and Temporomandibular Disorders, Hospital da Boca, Santa Casa da Misericórdia do Rio de Janeiro, Brazil
</affiliation>
</aut>
<aut id="aut2">
<label>Author-2</label>
<name>Bernardo Correia Lima</name>
<affiliation>
School of Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil
</affiliation>
</aut>
<aut id="aut3">
<label>Author-3</label>
<name>Bruno Luiz Baldessarini</name>
<affiliation>
American Dental Institute, United States
</affiliation>
</aut>
<aut id="aut4">
<label>Author-4</label>
<name>Pires J. D. M.</name>
<affiliation>
Department of Orofacial Pain and Temporomandibular Disorders, Hospital da Boca, Santa Casa da Misericórdia do Rio de Janeiro, Brazil
</affiliation>
</aut>
<aut id="aut5">
<label>Author-5</label>
<name>Rafael Coutinho Mello Machado5</name>
<affiliation>
School of Dentistry, Universidade Iguaçu, Nova Iguaçu, Brazil
</affiliation>
</aut>
</Author-Group>
<author-notes>
<corres-author>
<label>Corresponding-Author</label>
<name>Leonardo Brigido Metello Neves</name>
<address>
 Postgraduate Program in Dentistry, Estácio de Sá University, 366/201 Olegario Maciel Avenue, Barra da Tijuca, Rio de Janeiro, RJ, Brazil, Tel: +55 21 98788-4007.
</address>
</corres-author>
</author-notes>
<history>
<published-date>
<day>19</day>
<month>August  </month>
<year>2025</year>
</published-date>
</history>
<citation>
<author-names>
Metello Neves LB, Lima BC, Baldessarini BL
</author-names>
<published-year>2025</published-year>
<article-title>
The Simplified Pain Catastrophizing Scale (PCS-S): A Pilot Study of a Screening Tool for Orofacial Pain
</article-title>
<journal-short-name>Int J Oral Dent Health</journal-short-name>
<article-doi>10.23937/2469-5734/1510176</article-doi>
</citation>
<permissions>
<copyright>
<copyright-year>2025</copyright-year>
<copyright-holder>Metello Neves LB, et al. </copyright-holder>
<copyright-notes>
© This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
</copyright-notes>
</copyright>
</permissions>
<article-content>


<Abstract>
<p>
	
	
	Introduction: The management of orofacial pain (OFP) and temporomandibular disorders (TMD) is based on the biopsychosocial model, where pain catastrophizing is a critical predictor of worse clinical outcomes. Although the 13-item Pain Catastrophizing Scale (PCS) is considered the gold standard, it is impractical in high-volume clinics, creating a gap between research and practice.
</p>
<p>
	Objective: To develop and test the Simplified Pain Catastrophizing Scale (PCS-S), a three-item tool for rapid psychosocial screening in patients with OFP and TMD.
</p>
<p>
	Methodology: The PCS-S was developed through a literature review, item selection, and cultural adaptation and was subsequently applied in a pilot study involving 78 patients at a public hospital in Rio de Janeiro, Brazil. Administration took an average of 1.8 minutes, with scores greater than 7 indicating high catastrophizing. A subsample (n = 50) compared the PCS-S with the full PCS, calculating agreement percentages.
</p>
<p>
	Results: Of the 78 patients, 22% (n = 17) exhibited high catastrophizing. The PCS-S demonstrated 85% overall agreement with the full PCS, with item-level agreement ranging from 86-90%. Psychological comorbidities were identified in 65% of high-catastrophizing cases.
</p>
<p>
	Conclusion: The PCS-S is a feasible tool for screening catastrophizing, promoting multidisciplinary referrals, and aligning clinical practice with the biopsychosocial model within Brazil's Unified Health System (SUS).
</p></Abstract>
<Keywords>
<p>
	
	
	Catastrophizing, Implementation science, Orofacial pain, Temporomandibular disorder, Health services, Psychosocial screening
</p></Keywords>
<Abbreviations>
<p>
	
	
	OFP: Orofacial Pain; TMD: Temporomandibular Disorder; ACE: Adverse Childhood Experiences; HPA: Hypothalamic-Pituitary-Adrenal Axis; PCS: Pain Catastrophizing Scale; PCS-S: Simplified Pain Catastrophizing Scale; ANS: Autonomic Nervous System; CBT: Cognitive Behavioral Therapy
</p></Abbreviations>
<Introduction>
<p>
	
	
	Orofacial pain (OFP) and temporomandibular disorders (TMD) affect 10-15% of the adult population, representing a public health challenge due to their impact on quality of life and healthcare costs [1]. The biopsychosocial model recognizes pain as a dynamic process shaped by biological, psychological, and social factors [2,3]. Pain catastrophizing, defined as a negative cognitive-emotional response to actual or anticipated pain, is a potent modulator of the pain experience [4,5].
</p>
<p>
	Characterized by rumination (persistent focus on pain), magnification (overestimation of threat), and helplessness (inability to cope with pain) [6], catastrophizing is associated with activation of brain regions such as the anterior cingulate cortex, prefrontal cortex, and amygdala, suggesting a failure in descending pain modulation [7,8]. Clinically, high levels of catastrophizing correlate with increased pain intensity, functional disability, opioid use, and risk of chronicity [9,10].
</p>
<p>
	Despite its relevance, the 13-item Pain Catastrophizing Scale (PCS) [6], although psychometrically robust [11], is rarely used in high-volume clinics due to administration time and workload [12]. This research-practice gap results in the underdiagnosis of psychosocial factors, such as self-medication in TMD patients, which is associated with higher catastrophizing and prolonged pain [13]. To overcome this barrier, the Simplified Pain Catastrophizing Scale (PCS-S), a three-item tool designed for rapid psychosocial screening, was developed.
</p></Introduction>
<Objective>
<p>
	
	
	To present the development, methodology, and pilot application of the PCS-S, a three-item tool for rapid screening of catastrophizing in patients with OFP and TMD.
</p></Objective>
<Methodology>
<p>
	
	
	Study design
	
	A cross-sectional, descriptive pilot study was conducted at the specialized outpatient clinic of Hospital da Boca, Santa Casa da Miseric&#38;oacute;rdia do Rio de Janeiro, Brazil, in 2024. A convenience sample of 78 patients diagnosed with OFP and/or TMD according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) was recruited. Inclusion criteria included adults (&#38;ge; 18 years) with orofacial pain complaints lasting at least three months. Patients with severe neurological conditions, recent craniofacial trauma, or inability to complete questionnaires were excluded. Ethical approval was granted by Est&#38;aacute;cio de S&#38;aacute; University's Research Ethics Committee (approval number: 5.861.248) following CNS Resolution No. 466/2012.
</p>
<p>
	Development of the PCS-S
	
	The development of the PCS-S followed a systematic, multi-phase process to ensure brevity, content validity, and clinical applicability:
</p>
<p>
	&#38;bull; Literature Review: A comprehensive review focused on the original PCS [6], its Brazilian Portuguese version [11], and studies on catastrophizing in TMD patients [13,14].
</p>
<p>
	&#38;bull; Item Selection: Item selection was guided by the factor structure reported in the Brazilian validation of the PCS [11], prioritizing items from the most significant factors, helplessness and rumination, which are strongly associated with functional disability and maladaptive behaviors [4,13]. The final items correspond to specific items from the full PCS.
</p>
<p>
	&#38;bull; Cultural and Linguistic Adaptation: Cognitive interviews were conducted with 50 patients of varying educational levels to ensure clarity and accessibility. The scale was adjusted to include patients with tinnitus, a frequent comorbidity in TMD [13].
</p>
<p>
	&#38;bull; The final PCS-S consists of three items rated on a 0-4 Likert scale, with a total score ranging from 0 to 12. A score &#38;gt; 7 was established as the cutoff for high catastrophizing [4,6]. The scale is presented in Table 1, located at the end of this manuscript.
</p>
<p>
	Table 1: Simplified pain/tinnitus catastrophizing scale (PCS-S).
	
	Instructions: Mark how you feel about your pain.
	
	Scoring Scale: 0 = Never, 1 = Rarely, 2 = Sometimes, 3 = Often, 4 = Always. View Table 1
</p></Methodology>
<Procedures>
<p>
	
	
	The PCS-S was administered by a trained examiner, taking an average of 1.8 minutes. The full 13-item PCS was administered to a random subsample of 50 patients, with a 5-minute interval, taking an average of 5.2 minutes. Demographic and clinical data (PHQ-4) were also collected.
</p>
<p>
	Percentage agreement for each item
	
	Agreement was assessed in the 50-patient subsample by categorizing responses as "positive" (scores 3 or 4) or "negative" (scores 0, 1, or 2).
</p>
<p>
	&#38;bull; PCS-S Item 1 vs. Full PCS Items 6 and 11: Percent Agreement: 88% (44/50).
</p>
<p>
	&#38;bull; PCS-S Item 2 vs. Full PCS Items 8 and 9: Percent Agreement: 90% (45/50).
</p>
<p>
	&#38;bull; PCS-S Item 3 vs. Full PCS Item 7: Percent Agreement: 86% (43/50).
</p>
<p>
	&#38;bull; Overall Agreement for High Catastrophizing Classification (PCS-S &#38;gt; 7 vs. Full PCS &#38;gt; 30): 85% (42/50).
</p></Procedures>
<Results>
<p>
	
	
	Of the 78 patients, 22% (n = 17) showed high catastrophizing (PCS-S &#38;gt; 7), indicating a significant subgroup at elevated psychosocial risk. In the subsample of 50 patients, the PCS-S identified 22% (11/50) with high catastrophizing, compared to 24% (12/50) using the full PCS, with an overall agreement of 85%. Item-level agreement ranged from 86% to 90%, suggesting that the PCS-S effectively captures the constructs of rumination and helplessness. The average administration time for the PCS-S was 1.8 minutes (SD = 0.4), compared to 5.2 minutes (SD = 1.1) for the full PCS. Among patients with high catastrophizing on the PCS-S, 65% (11/17) had positive scores for anxiety and/or depression on the PHQ-4, highlighting the scale's utility in identifying psychological comorbidities.
</p></Results>
<Discussion>
<p>
	
	
	The pilot study results indicate that the PCS-S is a promising tool for screening pain catastrophizing, identifying 22% of patients with a high psychosocial risk, a critical factor associated with worse clinical outcomes [4,5]. The overall 85% agreement with the full PCS and item-level agreement of 86-90% suggest the PCS-S retains the core constructs of rumination and helplessness despite its brevity [11,13]. Its rapid administration (1.8 minutes) overcomes the barriers associated with the original PCS, which is often impractical in high-volume clinics [12].
</p>
<p>
	Catastrophizing amplifies pain perception through vicious cycles involving poor sleep quality, anxiety, and maladaptive behaviors such as self-medication [13-16]. Poor sleep, common in TMD patients, lowers pain thresholds and impairs emotional regulation, increasing rumination [17,18]. By identifying patients with high catastrophizing, the PCS-S facilitates early interventions such as Cognitive Behavioral Therapy (CBT), which has proven effective in modulating catastrophizing [19].
</p>
<p>
	In the context of the SUS, the PCS-S has the potential to promote equity in access to psychosocial screening, especially among vulnerable populations [20]. Its relevance is amplified in trauma-informed approaches, given the link between adverse childhood experiences (ACEs) and catastrophizing [5,21]. Implementing the PCS-S may catalyze a stepped-care model, directing intensive resources to those most in need [22-30].
</p></Discussion>
<Limitations>
<p>

	
	
	This pilot study has several limitations. The convenience sample, limited to a single center (n = 78), restricts generalizability. The comparison with the full PCS was conducted in a small subsample (n = 50), and the lack of formal statistical analyses prevents a robust evaluation of psychometric properties, such as sensitivity and specificity. Additionally, the cross-sectional design does not permit causal inference or assessment of the PCS-S's stability over time.
</p></Limitations>
<Conclusion>
<p>
	
	
	The Simplified Pain Catastrophizing Scale (PCS-S) is a practical and promising tool for psychosocial screening in patients with OFP/TMD. Its rapid administration and preliminary high agreement with the full PCS make it suitable for high-volume settings such as the SUS. The PCS-S facilitates the identification of patients at high psychosocial risk, promoting multidisciplinary referrals and aligning clinical practice with the biopsychosocial model. Further studies are necessary to formally validate the scale and confirm its applicability across different clinical contexts.
</p></Conclusion>
<Acknowledgments>
<p>
	
	
	We thank Hospital da Boca and Santa Casa da Miseric&#38;oacute;rdia do Rio de Janeiro for their logistical support. There are no conflicts of interest to declare.
</p></Acknowledgments>
<Funding-Sources>
<p>
	
	
	No external funding was received.
</p></Funding-Sources>
<p>
	&#38;nbsp;
</p>



<figures-and-tables>
	<text>All Figures and Tables link given in below</text>
	<link>https://clinmedjournals.org/articles/ijodh/international-journal-of-oral-and-dental-health-ijodh-12-176.php?jid=ijodh</link>
</figures-and-tables>



</article-content>

<article-references>
<title>References</title>

		 
<ref id="ref1">
    <label>Reference-1</label>
    <mixed-citation>
					Felin GC, da Cunha Tagliari CV, Agostini BA, Collares K (2024) Prevalence of psychological disorders in patients with temporomandibular disorders: A systematic review and meta-analysis J Prosthet Dent 132: 392-401.
				    https://pubmed.ncbi.nlm.nih.gov/36114016/
    </mixed-citation>
</ref>
<ref id="ref2">
    <label>Reference-2</label>
    <mixed-citation>
					Kovacevic I, Pavic J, Filipovic B, Vulinec SO, Ilic B, et al. (2024) Integrated approach to chronic pain-The role of psychosocial factors and multidisciplinary treatment: A narrative review. Int J Environ Res Public Health 21: 1135.
				    https://pubmed.ncbi.nlm.nih.gov/39338018/
    </mixed-citation>
</ref>
<ref id="ref3">
    <label>Reference-3</label>
    <mixed-citation>
					Ohrbach R, Dworkin SF (2016) The evolution of TMD diagnosis. Past, present, future. J Dent Res 95: 1093-1101.
				    https://pubmed.ncbi.nlm.nih.gov/27313164/
    </mixed-citation>
</ref>
<ref id="ref4">
    <label>Reference-4</label>
    <mixed-citation>
					H&#38;auml;ggman-Henrikson B, Bechara C, Pishdari B, Visscher CM, Ekberg E (2020) Impact of catastrophizing in patients with temporomandibular disorders - A systematic review. J Oral Facial Pain Headache 34: 379-397.
				    https://pubmed.ncbi.nlm.nih.gov/33290444/
    </mixed-citation>
</ref>
<ref id="ref5">
    <label>Reference-5</label>
    <mixed-citation>
					Sullivan MJL, Tripp DA (2024) Pain catastrophizing: Controversies, misconceptions, and future directions. J Pain 25: 575-587.
				    https://pubmed.ncbi.nlm.nih.gov/37442401/
    </mixed-citation>
</ref>
<ref id="ref6">
    <label>Reference-6</label>
    <mixed-citation>
					Sullivan MJL, Bishop SR, Pivik J (1995) The pain catastrophizing scale: Development and validation. Psychological Assessment 7: 524-532.
				    https://psycnet.apa.org/record/1996-10094-001
    </mixed-citation>
</ref>
<ref id="ref7">
    <label>Reference-7</label>
    <mixed-citation>
					Simic K, Savic B, Knezevic NN (2024) Pain catastrophizing: How far have we come? Neurol Int 16: 483-501.
				    https://pubmed.ncbi.nlm.nih.gov/38804476/
    </mixed-citation>
</ref>
<ref id="ref8">
    <label>Reference-8</label>
    <mixed-citation>
					Gracely RH, Petzke F, Wolf JM, Clauw DJ (2002) Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 50: 1333-1343.
				    https://pubmed.ncbi.nlm.nih.gov/12115241/
    </mixed-citation>
</ref>
<ref id="ref9">
    <label>Reference-9</label>
    <mixed-citation>
					Chan D, Saffari SE, Wong SBS, Yeo SJ, Wylde V, et al. (2024) The influence of pain catastrophizing on pain and function after knee arthroplasty. Sci Rep 14: 17174.
				    https://pubmed.ncbi.nlm.nih.gov/39060356/
    </mixed-citation>
</ref>
<ref id="ref10">
    <label>Reference-10</label>
    <mixed-citation>
					Sousa CRA, de Oliveira Lima Arsati YB, Velly AM, da Silva CAL, Arsati F (2023) Catastrophizing is associated with pain-related disability in temporomandibular disorders. Braz Oral Res 37: e070.
				    https://pubmed.ncbi.nlm.nih.gov/37436293/
    </mixed-citation>
</ref>
<ref id="ref11">
    <label>Reference-11</label>
    <mixed-citation>
					Sehn F, Chachamovich E, Vidor LP, Dall-Agnol L, de Souza ICC, et al. (2012) Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale. Pain Med 13: 1425-1435.
				    https://pubmed.ncbi.nlm.nih.gov/23036076/
    </mixed-citation>
</ref>
<ref id="ref12">
    <label>Reference-12</label>
    <mixed-citation>
					Kerns RD, Burgess DJ, Coleman BC, Cook CE, Farrokhi S, et al. (2022) Self-management of chronic pain. Psychologically guided core competencies for providers. Pain Med 23: 1815-1819.
				    https://pubmed.ncbi.nlm.nih.gov/35642906/
    </mixed-citation>
</ref>
<ref id="ref13">
    <label>Reference-13</label>
    <mixed-citation>
					Neves LBM, Guimar&#38;atilde;es AS, Rodrigues LLFR, Oliveira LB, Ramacciato JC, et al. (2019) Self-medication and pain catastrophizing in patients with myofascial pain: Are they related? Oral Dis. 25: 1672-1673.
				    https://pubmed.ncbi.nlm.nih.gov/31141271/
    </mixed-citation>
</ref>
<ref id="ref14">
    <label>Reference-14</label>
    <mixed-citation>
					de Oliveira Machado CA, Resende CMBM, Stuginski-Barbosa J, Simamoto PC (2024) Influence of sleep quality on pain characteristics, anxiety symptoms, and catastrophizing. BrJP 7: e20240043.
				    https://brjp.org.br/article/doi/10.5935/2595-0118.20240043-en
    </mixed-citation>
</ref>
<ref id="ref15">
    <label>Reference-15</label>
    <mixed-citation>
					Rad AA, Wippert PM (2024) Insights into pain distraction and the impact of pain catastrophizing on pain perception during different types of distraction tasks. Front Pain Res 5.
				    https://pubmed.ncbi.nlm.nih.gov/38322588/
    </mixed-citation>
</ref>
<ref id="ref16">
    <label>Reference-16</label>
    <mixed-citation>
					Ellingsen DM, Beissner F, Alsady TM, Lazaridou A, Paschali M, et al. (2021) A picture is worth a thousand words: Linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity. Pain 162: 1352-1363.
				    https://pubmed.ncbi.nlm.nih.gov/33230008/
    </mixed-citation>
</ref>
<ref id="ref17">
    <label>Reference-17</label>
    <mixed-citation>
					Reimann GM, Hoseini A, Ko&#38;ccedil;ak M, Beste M, K&#38;uuml;ppers V, et al. (2025) Distinct convergent brain alterations in sleep disorders and sleep deprivation: A meta-analysis. JAMA Psychiatry 82: 681-691.
				    https://pubmed.ncbi.nlm.nih.gov/40266625/
    </mixed-citation>
</ref>
<ref id="ref18">
    <label>Reference-18</label>
    <mixed-citation>
					H&#38;auml;m&#38;auml;l&#38;auml;inen T, Lappalainen P, Langrial SU, Lappalainen R, Kiuru N (2025) Mechanisms of change in an online acceptance and commitment therapy intervention for insomnia. Sci Rep 15: 2868.
				    https://pubmed.ncbi.nlm.nih.gov/39843686
    </mixed-citation>
</ref>
<ref id="ref19">
    <label>Reference-19</label>
    <mixed-citation>
					Zgierska AE, Edwards RR, Barrett B, Burzinski CA, Jamison RN, et al. (2025) Mindfulness vs cognitive behavioral therapy for chronic low back pain. JAMA Netw Open 8: e253204.
				    https://pubmed.ncbi.nlm.nih.gov/40193079/
    </mixed-citation>
</ref>
<ref id="ref20">
    <label>Reference-20</label>
    <mixed-citation>
					Jones A, Feldtmann EJ, Bellido C, Coughlin EC, Mhaskar RS, et al. (2025) Racial and ethnic differences in acute post-operative pain management. J Clin Anesth 104.
				    https://pubmed.ncbi.nlm.nih.gov/40328199/
    </mixed-citation>
</ref>
<ref id="ref21">
    <label>Reference-21</label>
    <mixed-citation>
					Aaron RV, Ravyts SG, Carnahan ND, Bhattiprolu K, Harte N, et al. (2025) Prevalence of depression and anxiety among adults with chronic pain. JAMA Netw Open 8: e250268.
				    https://pubmed.ncbi.nlm.nih.gov/40053352/
    </mixed-citation>
</ref>
<ref id="ref22">
    <label>Reference-22</label>
    <mixed-citation>
					Song L, Zhao M, Wang Y (2025) Exploring the causal relationship between chronic pain and temporomandibular disorders. Arch Oral Biol 106.
				    https://pubmed.ncbi.nlm.nih.gov/39965291/
    </mixed-citation>
</ref>
<ref id="ref23">
    <label>Reference-23</label>
    <mixed-citation>
					Kolev V, Malinowski P, Raffone A, Nicolardi V, Simione L, et al. (2025) Differential effects of meditation states and traits on the neural mechanisms of pain processing. bioRxiv.
				    https://www.biorxiv.org/content/10.1101/2025.05.20.655049v1
    </mixed-citation>
</ref>
<ref id="ref24">
    <label>Reference-24</label>
    <mixed-citation>
					Russin NH, Koskan AM, Manson L (2025) Integrative treatment strategies for chronic back pain. Int J Environ Res Public Health 22: 289.
				    https://pubmed.ncbi.nlm.nih.gov/40003514/
    </mixed-citation>
</ref>
<ref id="ref25">
    <label>Reference-25</label>
    <mixed-citation>
					Kim H, Lee S (2023) The impact of manual therapy on pain catastrophizing in chronic pain conditions. Phys Ther Rehabil Sci 12: 177-184.
				    https://www.jptrs.org/journal/view.html?doi=10.14474/ptrs.2023.12.2.177
    </mixed-citation>
</ref>
<ref id="ref26">
    <label>Reference-26</label>
    <mixed-citation>
					Mateus MD, Mari JJ, Delgado PG, Almeida-Filho N, Barrett T, et al. (2008) The mental health system in Brazil: Policies and future challenges. Int J Ment Health Syst 2: 12.
				    https://pubmed.ncbi.nlm.nih.gov/18775070/
    </mixed-citation>
</ref>
<ref id="ref27">
    <label>Reference-27</label>
    <mixed-citation>
					Dalalishvili S, Margvelashvili V, Nikolaishvili M (2025) Bruxism: Implications for human health and well-being. Journal of Biosciences and Medicines 13.
				    https://www.scirp.org/journal/paperinformation?paperid=140472
    </mixed-citation>
</ref>
<ref id="ref28">
    <label>Reference-28</label>
    <mixed-citation>
					Weerakkody L, Lau J, Vegunta K, Thomas DC, Balasubramaniam R (2025) Genetics, lifestyle and psychosocial considerations in orofacial pain. Pathological Basis of Oral and Maxillofacial Diseases 639-657.
				    https://research-repository.uwa.edu.au/en/publications/genetics-lifestyle-and-psychosocial-considerations-in-orofacial-p
    </mixed-citation>
</ref>
<ref id="ref29">
    <label>Reference-29</label>
    <mixed-citation>
				Jiang H (2024) Gut dysbiosis in patients with chronic pain. Front Immunol 15: 1367890.
				    #
    </mixed-citation>
</ref>
<ref id="ref30">
    <label>Reference-30</label>
    <mixed-citation>
					Osborne NR, Davis KD (2022) Sex and gender differences in pain. Int Rev Neurobiol 164: 277-307.
				    https://pubmed.ncbi.nlm.nih.gov/36038207/
    </mixed-citation>
</ref>


</article-references>
</body>
</article>