Clinical and radiographic findings in HD-SOD of 66cases diagnosed between 1987-2020.

Table 1: Clinical and radiographic findings in HD-SOD of 66cases diagnosed between 1987-2020.

Reference	Case no	Age/sex	Quadrant	Facial asymmetry	Skin manifestation	Hypodontia	Dental abnormality	Radiographic bone pattern
Miles, et al. [1] (2 cases)	1	15/M	R	+	Hypertrichosis	1^st and 2^nd pm	All teeth hypoplastic	Dense, granular
Miles, et al. [1] (2 cases)	2	3.5/F	L	+	None	None	Hypoplastic 1^stand 2^nd primary molars	Granular
Danforth, et al. [2] (8 cases)	3	6/M	R	NS	None	2^nd pm	Dysplastic primary 1^st molar	Mottled, ill-defined, radiopaque
	4	4/F	R	+	None	1^st and 2^nd pm	Root resorption	Mottled, ill defined, radiopaque
	5	8/M	L	+	None	1^st, 2^nd pm, canine	Primary canine and 1^stmolar dysplastic, root resorption	Mottled, ill defined, radiopaque
	6	6/F	R	NS	NS	1^st and 2^nd pm	Primary 1^st molar dysplastic, root resorption	Mottled, ill defined, radiopaque
	7	12/M	R	NS	NS	2^nd pm	Root resorption	Mottled, ill defined, radiopaque
	8	8/M	R	+	NS	2^nd pm	Root resorption	Mottled, ill defined, radiopaque
	9	6/F	L	NS	NS	1^st pm	Root resorption	Mottled, ill defined, radiopaque
	10	28/F	R	NS	NS	1^st and 2^ndpm	None	Mottled, ill defined, radiopaque
De Salvo, et al. [3] (1 case)	11	7/F	L	+	Lip hypopigmentation	1^st and 2^nd pm	Larger and hypoplastic primary molars root resorption	Ill-defined, coarse, irregular pattern elevated sinus floor
Packota, et al. [4] (12 cases)	12	14/M	L	none	Depression of the cheek cleft of the vermillion border	1^st and 2^nd pm, 3^rdmolar, impacted 1^st and 2^ndmolars	Long 1^st primary molar root, obliterated pulp chamber	Sclerotic and aligned in a vertical fashion, smaller sinus
Packota, et al. [4] (12 cases)	(13-23)	5 to 27 (age not given for 5 patients)/7M, 5F	8L/4R	NS	NS	Missing teeth, delayed eruption	Enlarged crowns enlarged roots splayed roots root resorption enlarged pulps abnormal spacing	Sclerosis thickened trabeculae vertical trabeculation, smaller sinus
Paticoff, et al. [5] (2 cases)	24	23/M	R	+	Hairy nevus	1^stpm	Hypoplastic teeth	Hyperplastic bone
Paticoff, et al. [5] (2 cases)	25	7/M	R	+	Hypertrichosis	1^st pm missing delayed eruption	Hypoplastic teeth	Hyperplastic bone
Jones, Ford [6] (1case)	26	7/M	L	None	Becker’s nevus	1^st, 2^nd pm	Root resorption of 1^st molar	Thickened vertical defect at canine vertically oriented
Prusack, et al. [7] (1 case)	27	3/F	R	+	None	1^st, 2^nd pm	Root resorption of primary molars	Ground glass, vertical orientation, smaller sinus (CT)
Velez, et al. [8] (2 cases)	28	3.5/M	R	NS	Hyperpigmentation hypertrichosis	NS	None	None
Velez, et al. [8] (2 cases)	29	14/F	L	+	None	NS	None	Expansive diffuse radiopaque, sclerosis, thickened bone trabeculae
Becktor, et al. [9] (4 cases)	30	3/F	L	NS	Erythema on left cheek	1^st pm, 3^rd m (Delayed 1^st pm, 1^st and 2^nd m)	Obliterated pulp chambers and root resorption of primary molars	Sclerotic, sinus involvement
	31	8/M	L	NS	None	2^nd pm (Delayed 1^st pm, 1^st and 2^nd m)	Splayed roots, obliterated pulp chambers and root resorption of primary molars	Sclerotic, sinus involvement (CT), bone scintigraphy (no pathologic activity)
	32	2/M	L	NS	Erythema left cheek	1^st,2^nd pm (Delayed 1^st and 2^nd m)	Splayed roots, obliterated pulp chambers, root resorption of primary molars	Sclerotic, no sinus involvement
	33	3/M	L	NS	None	1^st pm	Splayed roots, large pulp cavities of 1^stand 2^nd primary molars	Sclerotic, sinus involvement
Drake [10] (1 case)	34	7/M	L	+	NS	1^st, 2^nd pm	Larger primary molars with atypical morphology	Ill-defined, radiopaque
Welsch, et al. [11] (1 case)	35	5/M	L	+	Becker’s nevus	1^st, 2^ndpm	Abnormally shaped and misaligned teeth	Subtle coarsening of bone trabeculae
Armstrong, et al. [12] (2 cases)	36	3.5/M	L	+	NS	1^stm	Enlarged, spaced teeth and hypoplastic upper left deciduous first molar	Ill-defined, radiodensity
Armstrong, et al. [12] (2 cases)	37	3.5/M	L	+	NS	1^st pm	Enlarged pulp chambers,	Diffuse ill-defined, radiodensity
Gavalda, et al. [13] (1 case)	38	8/M	R	+	NS	2^nd pm	None	None
Bhatia, et.al. [15] (1 case)	39	7/M	L	NS	Ectopic eyelashes	1^st, 2^nd pm	None	None
Koenig, et al. [16] (1 case)	40	26/F	R	+	Hypertrichosis commissural lip cleft hyperlinear palms erythema	1^st, 2^nd pm	None	Sclerotic, ground glass, vertical alveolar defect at distal of canine
Yassin, Rihani [17] (1 case)	41	12/M	L	+	Midfacial diffuse hyperkeratotic erythematous lesion upper lip hypopigmentation unidentifiable vermilion border	2^nd pm	Enlarged pulps abnormal root morphology of left deciduous and permanent molars	Smaller sinus, radiopacity with irregular bone trabecular pattern distal to maxillary left canine
Porwal, et al. [18] (1 case)	42	34/F	R	+	hypertrichosis hypopigmented streak	1^st, 2^nd pm	None	Smaller sinus
Özpınar, et al. [19] (1 case)	43	47/F	L	NS	None	None	None	Thickened bone trabeculae
Kuklani, Nair [20] (1 case)	44	4/M	L	+	Hypertrichosis increased fullness of upper lip and cheek erythema	1^st and 2^nd pm delayed eruption	None	Trabeculae orientation vertically, thickened bony trabaculae, smaller sinus
Pandey, et al. [21] (1 case)	45	17/F	L	+	Hypertrichosis	1^st, 2^nd pm	None	None
Whitt, et al. [22] (5 cases)	46	4/F	R	None	None	1^st, 2^nd pm	Hypoplastic primary 1^st molar	None
	47	14/M	R	None	None	None	Hypoplastic primary 2^nd molar abnormal spacing	Sinus involvement, smaller sinus, vertically oriented trabeculae. pattern
	48	11/F	R	None	None	1^st pm missing teeth delayed eruption	Hypoplastic primary 1^stm abnormal spacing	Ill-defined, radiodensity, granular trabeculae, vertically oriented trabeculae
	49	4/M	R	None	None	2^nd molar delayed eruption	Hypoplastic 1^st pm	Ill-defined density, smaller sinus, granular trabecular bone
	50	9/M	R	None	None	2^nd pm delayed eruption	Root resorption	Sinus involvement, ill-defined, radiodensity vertically oriented trabeculae
Minett, Daley [23] (1 case)	51	5/M	R	None	Hyperpigmentation of right cheek fordyce granules	-	Primary 1^st m dysplastic	Hyperostotic ground glass
Friedlander- Barenboim, et al. [24] (1 case)	52	12/M	R	None	Hypertrichosis nevus	Canine, premolars, 2^nd and 3^rd molars	Large primary molars root resorption	Altered, ill-defined radiopacity sinus involvement (ct available)
Gonzalez-Arrigada, et al. [25] (3 cases)	53	22/F	R	+	Hypertrichosis commissural lip clefting	1^st, 2^nd pm	None	Ground glass, ill-defined radiopacity, smaller sinus
Gonzalez-Arrigada, et al. [25] (3 cases)	54	17/M	R	+	-	1^st, 2^nd pm	None	Large and irregular bone trabeculae
	55	5/M	R	+	Hypertrichosis unilateral lip clefting	2^nd deciduous molar	None	Altered, ill-defined radiodensity smaller sinus
Shah, et al. [26] (1 case)	56	19/F	Midline	None	Hypertrichosis erythematous lesion	-	Hypoplastic, yellowish upper incisors abnormal spacing	Ill-defined, coarse, irregular trabecular bone pattern
Azevedo, et al. [27] (1 case)	57	6/F	R	None	None	1^st, 2^nd pm	Irregular morphological aspect root resorption	Altered, mottled ill-defined radiopacity vertical trabeculae orientation
Rai, et al. [28] (3 cases)	58	45/M	R	None	Hypertrichosis	-	Root resorption	Ill-defined granular bone idiopathic osteosclerosis
	59	45/M	R	None	Hypertrichosis	1^stm	None	None
	60	24/M	R	+	None	-	None	None
Agrawal, et al. [29] (1 case)	61	13/M	L	+	None	Delayed eruption	None	Altered trabecular pattern, sinus involvement
Smith, et al. [30] (3 cases)	62	14/F	L	None	None	1^stpm, 2^ndpm	Extending to the pulp, dilacered roots	Ill-defined, coarse, bone trabeculation, vertically oriented trabeculation
	63	12/F	L	+	Hyperpigmentation	2^nd pm	-	Altered trabecular pattern ill defined, sclerotic appearing bone
	64	11/F	L	None	None	None	Hypoplastic tooth root dilaceration	Sclerotic bone
Heggie, Gastshore [31]	65	7/M	R	None	Widespread erythema ulceration	1^stpm, 2^nd pm	Root resorption multiple pulp stones	Smaller right sinus irregular shaped, superficially
(1 case)								Absorbed trabecular and haversian bone with resting lines
Present case (1 case)	66	10/F	R	+	Hypertrichosis	2^nd pm	None	Altered, irregular, vertically oriented trabeculae

None = negative observation, + = positive observation, pm=premolar, m = molar, NS = not stated