Table 1: Overview table with reported cases of interstitial keratitis secondary to Epstein-Barr virus.
Case Series (reference) | Number of Cases | Laterality | Anterior Examination | Virology | Sex | Median Age | Treatment | Resolution |
Palay, et al. [4] | 1 | Bilateral | Confluent full- thickness stromal opacities with 360° intrastromal vascularization | Anti-VCA IgG (+); EBNA (+); EBEA (+) | M | 21 MO | Topical corticosteroids | Yes |
Matoba, et al. [5] | 7 | 2 Bilateral; 5 Unilateral | Multifocal, pleomorphic anterior stromal obscurities with clear intervening with minimal neovascularization | (+) monospot (1 case); (+) anti- viral capsid (1 case); (+) anti-VCA (6 cases); (+) EBNA (3 cases) | 4F; 3M | 14.71 YO | Prednisolone, dexamethasone, artificial tears, fluoromethalone | 3/7 |
Pinnolis, et Al. [6] | 1 | Bilateral | Numerous nummular stromal opacities | (+) monospot; (+) EBV indirect fluorescent antibody titer | M | 16 YO | Oral prednisone, prednisolone 1% drops | Yes |
Wong, et al. [1] | 1 | Bilateral | Peripheral keratitis with corneal stromal edema and confluent areas of white opacities | (-) common viral nucleic acids RT- PCR | M | 30 YO | Topical acyclovir ointment adjunct to systemic acyclovir; topical steroid | Yes |
Ding, et al, [7] | 1 | Bilateral | Corneal edema and Descemet membrane folds | (+) RT- PCR tear film for EBV | F | 84 YO | Artificial tears, ganciclovir eye drops, flumetholon, tarivid | Yes |
Matoba and Jones, et al. [8] | 2 | 1 Bilateral; 1 Unilateral | Multifocal subepithelial infiltrates with intraepithelial granularity | (+) anti- VCA IgG (both cases); (+) EBNA (1 case) | 2F | 29.5 YO | Topical flurometholone 0.1%, prednisolone 1% drops | Yes |
Matoba, et al. [5] | 1 | Bilateral | Recurring multifocal epithelial dendrites with pleomorphic, nummular opacities and corneal edema | EBV viral DNA detected by PCR; confirmed by serologies | F | 66 YO | Trifluorothymidine, 1% prednisolone drops, oral acyclovir | No |
Pellerin, et al. [2] | 1 | Bilateral | Nummular stromal opacities +/- intralesional branching ghost vessels | (+) EBV EBEA | F | 39 YO | 1% prednisolone drops | Unknown |
M: Male; F: Female; YO: Years Old; MO: Months Old