Table 3: Comparison of CD4+CD25+Treg cells, Foxp3 mean fluorescence index, and cytokine levels from CD4+CD25+Treg cell supernatants between baseline-during acute panuveitis attack (sample 1), at termination of azathioprine therapy (sample 2), and while panuveitis was inactive on maintenance therapy of interferon alfa-2a (sample 3) offive patients with Behçet uveitis.

Blood samples Median ± SD
Mean ± SEM
Range
Percentage of CD4+CD25+Treg cells Foxp3 MFI IFN-γ (pg/ml) TNF-α (pg/ml) IL-4 (pg/ml) IL-17 (pg/ml) IL-18 (pg/ml) IL-10 (pg/ml)
Sample 1 5.30 ± 4.06
9.86 ± 9.10
1.50-22.40 		543 ± 67.79
582.4 ± 151.59
398-792 		1.34 ± 8.48
9.82 ± 18.96
0-43.7 		1.34 ± 0.67
1.75 ± 1.50
0.52-4.20 		20.5 ± 5.55
23.02 ± 12.41
14.0-44.2 		7.67 ± 3.42
8.22 ± 7.66
0-17.2 		1.62 ± 0.38
1.45 ± 0.85
0.16-2.47 		0.12 ± 0.45
0.81 ± 1.01
0-2.11
Sample 2 1.80 ± 2.89
4.62 ± 6.46
0.30-15.90 		340 ± 75.86
415 ± 169.63
248-680 		2.17 ± 0.70
2.33 ± 1.58
0.12-4.45 		2.22 ± 3.95
6.03 ± 8.85
0.82-21.80 		15.7 ± 1.24
16.14 ± 2.78
12.4-19.4 		3.44 ± 2.05
4.52 ± 4.59
0-12.3 		3.68 ± 0.96
3.58 ± 2.16
0.16-6.15 		1.43 ± 0.42
1.42 ± 0.94
0-2.52
Sample 3 0.80 ± 0.87
1.62 ± 1.94
0.60-5.10 		439 ± 28.41
444.6 ± 63.53
347-514 		2.59 ± 0.77
2.30 ± 1.72
0.12-4.74 		2.56 ± 2.26
5.68 ± 5.06
2.10-13.90 		17.7 ± 3.75
19.79 ± 8.38
9.99-29.4 		7.67 ± 2.89
9.72 ± 6.47
3.44-19.70 		1.17 ± 0.46
1.12 ± 1.04
0-2.26 		2.39 ± 0.51
2.69 ± 1.15
1.43-3.91
p* 0.09 0.09 0.94 0.36 0.95 0.36 0.36 0.09
Paired groups comparison p†
1 vs. 3
2 vs. 3
1 vs. 2 		0.06
0.18
0.31 		0.12
0.81
0.06 		>0.99
>0.99
>0.99 		0.18
0.81
0.12 		0.81
0.81
0.31 		0.62
0.37
0.43 		0.62
0.12
0.18 		0.06
0.31

0.43


MFI: Mean Fluorescence Index, IFN: Interferon, TNF: Tumor Necrosis Factor, *: Friedman; †: Wilcoxon