Table 2: Atypical variants of late and early onset AD (modified after [16]).
|
AD subtype |
Clinical presentation |
Pathology |
Progression rate |
CSF Ab and tau levels |
|
Typical LOAD (50-75%) |
Amnestic/non-amnestic |
Both hippocampal and cortical (“both impaired”) |
Typical AD |
Typical AD |
|
Limbic-predominant LOAD (15-35%) |
Amnestic |
Medial-temporal lobe (“hippocampal”) |
Slower |
Similar |
|
Hippocampal-sparing LOAD (10-25%) |
Non-amnestic |
"Cortical", sparing of medial temporal lobes |
Faster |
Similar |
|
Minimal atrophy LOAD (10-17%) |
Unclear |
Minimal |
Slowest |
Aβ ↑, tau ↓ |
|
Typical EOAD (75%) |
Amnestic/non-amnestic |
Hippocampal and cortical |
Typical AD |
Similar to typical AD |
|
Atypical EOAD (25%) |
Non-amnestic |
Posterior cortical |
Faster |
Similar to typical AD |