| Author; No. of patients | Design; Duration, Intervention | Outcomes | Results |
| ARIPIPRAZOLE | |||
| Warsi et al. (2005) [68] n=1 | CR 2 months SCH + AD ARI (20 mg/d) | Psychiatric symptoms (BPRS) Daily alcohol used Alcohol craving (PCS, SRCS) | ARI was associated with an improvement in psychiatric symptoms, cessation of daily alcohol intake and reduction in alcohol craving |
| Beresford et al. (2005) [69] n=10 | Pros, OL study 8 weeks SCH + COD ARI (maximum 15 mg/d) | Psychiatric symptoms (BPRS) Cocaine and alcohol craving (UTS, BCRS) | Positive UTS dropped significantly (p< 0.001) Mean cocaine (p=0.026) and alcohol (p=0.006) craving scores significantly declined Declining psychosis scores were significantly associated with declining cocaine and alcohol craving (p< 0.01) |
| Brown et al. (2005) [70] n=20 | OL study 12 weeks BD (n=19) or SAD (n=1) + AD (n=17) and/or COUD (n=9) ARI (up to 30 mg/d) | Psychiatric symptoms (YMRS, HDRS, BPRS) Substance craving (VAS) Substance use (days of use/week, money spent on substances/week and UTS) | ARI was associated with significant improvements in psychiatric symptoms (p< 0.05), significant reductions in alcohol craving (p=0.003) and money spent on alcohol/week (p=0.042) and significant reductions in cocaine craving (p=0.014). No significant changes were observed in days/week of alcohol and cocaine use, and in money spent on cocaine/week |
| Kim et al. (2010) [37] n=139 | Pros, RCT 8 weeks SCH + ND OLZ (n=32) or RIS (n=41) or ARI (n=31) or HAL (n=35) | Psychopathology (SANS, SAPS) EPS (AIMS) Severity of ND and cigarette craving (FTQ) | No significant differences in the degrees of change in psychiatric symptoms among the four groups. At 8 weeks, HAL was associated with higher EPS (p< 0.01).HAL was associated with less reduction in the severity of ND (p< 0.01) and cigarette craving (p< 0.01) compared to AAP. Among AAP, RIS increased cigarette craving (p=0.03), there were no significant changes in ND severity and cigarette craving associated with OLZ, and ARI showed a reduction in both severity of ND and cigarette craving (p< 0.01) |
| Bruno et al. (2014) [71] n=20 | OL study 8 weeks SAD + OD + MMT ARI (10 mg/d) + TOP (200 mg/d) | Tapering and suppression of MET | ARI + TOP was effective to achieve MET suppression reducing clinical symptoms |
| Farnia et al. (2014) [53] n=45 | Pros, DB, RCT 1 year follow-up AMP induced psychosis RIS (4 mg/d) or ARI (15 mg/d) | Psychopathology (SANS, SAPS) | SANS and SAPS scores decreased significantly in both groups. Mean SAPS score reduction was greater in the RIS group (p< 0.001). Mean SANS score reduction was greater in the ARI group (p = 0.08) |
| AMISULPRIDE | |||
| Dervaux and Cazali (2007) [72] n=1 | CR Over 25 months SCH + AD CLO (600-1200 mg/d) + AMS (600 mg/d) | Psychopathology Alcohol addictive behaviour | CLO + AMS was effective in controlling psychiatric symptoms and alcohol addictive behaviour |
| Máñez et al. (2010) [73] n=97 | Pros study 9 months SUD (alcohol, cannabis, cocaine and heroin + psychotic symptoms AMS in two ranges (100-300 mg/D or >400 mg/d, mean dose 493.5 ± 197.1 mg/d) | Psychosocial distress Craving Psychosocial functioning | Overall improvement in their psychological distress, a decrease in carving and an improvement in their psychological and psychosocial functioning |
| ZIPRASIDONE | |||
| Stuyt et al. (2006) [38] n=55 | Ret, OL 2 years SCH (61%) or SAD (54%) + SUD or AUD Polyvalent SUD (34%), Alcohol (27%), Cocaine (16%), other SUD (21%) OLZ (2.5-30 mg/d, mean dosage 18.7 mg/d) (n=15) or RIS (n=16) (2-8 mg/d, mean dosage 3.9 mg/d) or ZIP (60-160 mg/d, mean dosage 132.8 mg/d) (n=10) or TAP depot (n=10) | Retention rate Success in completing a DD Programme | RIS and ZIP had higher rates of retention compared to OLZ (p=0.0002 and p=0.004, for RIS and ZIP respectively) and TAP (p=0.003 and p=0.03, for RIS and ZIP, respectively). No significant differences in length of stay were found between RIS and ZIP. 88% of RIS patients and 64% of ZIP completed the DD program, whereas only 40% of patients taking TAP and 33% of patients in the OLZ successfully completed the program. This difference in successful completion was statistically significant for RIS vs OLZ (p=0.02) and TAP (p=0.017) |