Table 4: Prognostic factors implicated in favorable and unfavorable outcomes in patients with PNES


FAVORABLE UNFAVORABLE


Children

Acceptance of nonepileptic nature of episodes

Family structure that supports autonomy

Female

Having friends currently

Having good relationships with friends as a child

Higher ability to express emotions

Higher intelligence & education

Independent lifestyle

Less dramatic PNES:

- No positive motor features

- No ictal incontinence or biting

- No admissions to ICU

- No pseudostatus with intubation

Less extreme scores on traits defining emotional dysregulation

Less tendency to dissociate

Shorter duration of PNES

Younger age at diagnosis
Adults

Co-existing epilepsy

Disbelief of diagnosis

Family structure that supports dependency and illness

Long history of psychiatric disorders

Longer duration of PNES

Male

Ongoing physical and/or sexual abuse

Ongoing psychosocial stressors

Pending litigation

Persistently somatizing patient

Reluctant self-disclosure

Restricted expression of anger and positive feelings

Unemployment/Disability

References: Barry & Sanborn [41], Reuber et al [52]. LaFrance &Devinsky [19], Durrant J [53], and Ettinger et al. [66].