Table 2: Literature review of studies comparing stimulation cycles in vagus nerve stimulation for drug-resistant epilepsies

Author/year Cases (No) Responders (No) Stimulationcycleused Frequency Mean follow-up (months) Conclusions
Scherrmann J et al. 2001 [2] 95 38 7 sec on/30 sec off
30 sec on/5 min off
20 Hz
30 Hz
15.8 ± 10.3 Better outcome in patients with stimulation-on period of 30 sec
DeGiorgio CM et al. 2001 [3] 154 NR 12-66 sec off/7-60 sec on
1.8 min off/7-60 sec on
3 min off/7-60 sec on
5 min off/7-60 sec on
30 Hz 12 Patients with 30 sec on and 5 min off continue to respond or improve in their response over 1 year period. Some patients may benefit from reductions in off time (increases duty cycle)
Labar D et al. 2004 [1] 269 153 > 3 min off (standard cycle)
< 1.8 min off(rapid cycle)
NR 12 No differences between standard or rapid cycle
DeGiorgio C et al. 2005 [4] 61 18 7 seconds on/18 seconds off
30 seconds on/30 seconds off
30 seconds on/3 minutes off
20-30 Hz 3 In the first 3 months of therapy, initial setting of 30 seconds on/3 minutes off is well tolerated, and produce the most 75% responders