Advantages

Disadvantages

Toxicity is less

Mechanical resistance is less

Enhanced Biocompatibility

Difficulty in controlling pore size

Possess mucoadhesive character

May contract

Possess stability

Electrospinning is difficult for pure chitosan

Drug targeting is site-specific

Preparation by crosslinking can affect intrinsic properties of chitosan

Therapeutic index of the drug is increased

Low solubility in neutral and alkaline pH

Frequent, expensive and unpleasant dosing is prevented

Method of preparation must be changed according to the drug to be delivered