Table 3: Physicochemical and Encapsulation properties of MTX Loaded PLGA nanoparticles, according to increase of drug value; n = 3.
| Methotrexate (mg) | Mean size (nm) | PDI | ZP (mv) | EE (%) | DL (%) |
|---|---|---|---|---|---|
| 0 | 99.19 ± 14.51 | 0.119 | - 5.54 | - | - |
| 5 | 184.5 ± 14.3 | 0.405 | - 3.66 | 62.96 | 5.72 |
| 10 | 217.3 ± 16.4 | 0.419 | - 2.28 | 64.35 | 5.94 |
| 15 | 240.5 ± 21.7 | 0.149 | - 4.02 | 67.58 | 7.48 |
| 20 | 286.3 ± 23.6 | 0.304 | - 2.17 | 71.21 | 8.22 |