Table 1: Different sizes particles can reach location in vivo [15].
Particle size |
Can reach the location in vivo |
> 12 mm |
Can be blocked at the end of the capillary or stay in the liver, stomach, as well as in the organs with tumors |
7~12 mm |
Can be ingested by the lungs by intravenous injection |
2~12 mm |
Can be ingested by capillary network, not only can reach lung, but also can reach liver and spleen |
1 mm |
The size is most likely to be devoured by white blood cells |
0.1~0.2 mm |
Can be injected through the vein, artery or abdominal cavity, and in the reticuloendothelial system be absorbed by macrophages from the blood |
< 50 nm |
Can be transmitted through the liver endothelium or through lymph to the spleen, and can also reach bone marrow, as well as tumor tissue and liver |