Effect of epinephrine on anti-inflammatory cytokine production by PBMC.

Table 2: Effect of epinephrine on anti-inflammatory cytokine production by PBMC.

Epinephrine	Non-stimulated	LPS-stimulated	HT-29-induced
0	0.99 ± 0.23	2.36 ± 0.67	1.59 ± 0.34
0.025 ng/ml	0.96 ± 0.1	2.25 ± 0.51	1.44 ± 0.40
0.05 ng/ml	0.89 ± 0.10	2.30 ± 0.43	1.43 ± 0.13^*
0.10 ng/ml	1.00 ± 0.12	2.46 ± 0.55	1.55 ± 0.09

Non-stimulated PBMC or cells stimulated with either LPS or co-cultured with HT-29 colon cancer cell line, were incubated for 24 hrs without (0) or with epinephrine at concentrations as indicated. The level of IL-10 in the supernatants was tested by ELISA. The results are expressed as Mean ± SEM of 4 experiments (4 different donors). Asterisk represents statistically significant difference from cells incubated without epinephrine (*p < 0.05).