Table 3: AIRE deficiency symptoms compared to checkpoint inhibition immune-related adverse events.

AIRE deficiency/APECED Checkpoint inhibition
Rash X X
Candidiasis X
Pruritis X
Vitiligo X X
Diarrhea X X
Colitis X
Constipation X X
Pernicious anemia X
Hypothyroidism X X
Fatigue X X
Increased Aminotransferases X
Pneumonitis X
Hypogonadism X
Adrenal Insufficiency X X
Parathyroid Insufficiency X
Hepatitis X X
Arthralgia X
Malabsorption X

X- Indicates that the symptom is present.