Table 3: AIRE deficiency symptoms compared to checkpoint inhibition immune-related adverse events.
AIRE deficiency/APECED | Checkpoint inhibition | |
---|---|---|
Rash | X | X |
Candidiasis | X | |
Pruritis | X | |
Vitiligo | X | X |
Diarrhea | X | X |
Colitis | X | |
Constipation | X | X |
Pernicious anemia | X | |
Hypothyroidism | X | X |
Fatigue | X | X |
Increased Aminotransferases | X | |
Pneumonitis | X | |
Hypogonadism | X | |
Adrenal Insufficiency | X | X |
Parathyroid Insufficiency | X | |
Hepatitis | X | X |
Arthralgia | X | |
Malabsorption | X |
X- Indicates that the symptom is present.