Table 1: Checkpoint molecules and their specific antibodies.
Checkpoint Molecule | Specific Antibody | Nature of Antibody | (Trade name) and producer |
---|---|---|---|
CTLA-4 | Ipilimumab | Human, IgG1κ | Yervoy®, Bristol-Myers Squibb |
Tremelimumab | Human, IgG2κ | Pfizer, Astra-Zeneca | |
PD-1 | Nivolumab | Human, IgG4κ | Opdivo®, Bristol-Myers Squibb |
Pembrolizumab | Humanized mouse, IgG4κ | Keytruda®, Merck | |
PD-L1 | Pidilizumab | Humanized mouse, IgG1κ | Medivation (Pfizer) |
Atezolizumab | Humanized IgG1κ | Tecentriq®, Genentech | |
Avelumab | Humanized IgG1λ | Bavencio®, Merck, KGaA and Pfizer | |
Durvalumab | Humanized IgG1κ | Imfinzi™, AstraZeneca |