Table 1: Checkpoint molecules and their specific antibodies.

Checkpoint Molecule Specific Antibody Nature of Antibody (Trade name) and producer
CTLA-4 Ipilimumab Human, IgG1κ Yervoy®, Bristol-Myers Squibb
Tremelimumab Human, IgG2κ Pfizer, Astra-Zeneca
PD-1 Nivolumab Human, IgG4κ Opdivo®, Bristol-Myers Squibb
Pembrolizumab Humanized mouse, IgG4κ Keytruda®, Merck
PD-L1 Pidilizumab Humanized mouse, IgG1κ Medivation (Pfizer)
Atezolizumab Humanized IgG1κ Tecentriq®, Genentech
Avelumab Humanized IgG1λ Bavencio®, Merck, KGaA and Pfizer
Durvalumab Humanized IgG1κ Imfinzi™, AstraZeneca